Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 15532..16175 Replicon plasmid plas1
Accession NZ_CP099908
Organism Escherichia albertii strain 112_1_EW_A

Toxin (Protein)


Gene name vagD Uniprot ID -
Locus tag NIY89_RS23725 Protein ID WP_256876211.1
Coordinates 15532..15948 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID -
Locus tag NIY89_RS23730 Protein ID WP_256876210.1
Coordinates 15945..16175 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NIY89_RS23700 (10583) 10583..10924 - 342 Protein_12 protein RepA -
NIY89_RS23705 (11461) 11461..12057 - 597 WP_256876215.1 hypothetical protein -
NIY89_RS23710 (12045) 12045..12314 - 270 WP_256876214.1 hypothetical protein -
NIY89_RS23715 (12633) 12633..14204 + 1572 WP_256876213.1 ATP-binding protein -
NIY89_RS23720 (14412) 14412..15392 - 981 WP_256909404.1 hypothetical protein -
NIY89_RS23725 (15532) 15532..15948 - 417 WP_256876211.1 type II toxin-antitoxin system VapC family toxin Toxin
NIY89_RS23730 (15945) 15945..16175 - 231 WP_256876210.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
NIY89_RS23735 (16744) 16744..17157 + 414 WP_000465043.1 hypothetical protein -
NIY89_RS23740 (17159) 17159..17941 + 783 WP_021533580.1 site-specific integrase -
NIY89_RS23745 (18114) 18114..18467 + 354 WP_000864812.1 colicin M immunity protein -
NIY89_RS23750 (18517) 18517..19332 - 816 WP_000449473.1 lipid II-degrading bacteriocin colicin M -
NIY89_RS23755 (19575) 19575..20102 + 528 WP_000203268.1 colicin B immunity protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - espL2 / espL2 1..89078 89078


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-49)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15080.41 Da        Isoelectric Point: 6.7125

>T249912 WP_256876211.1 NZ_CP099908:c15948-15532 [Escherichia albertii]
VNKIYMLDTNICSFIMREQPEAVLKRLEQAVLRGHRIVVSAITYSEMRFGATGPKASPRHVQLVDAFCERLDAVLPWDRA
AVDATTEIKVALRLAGTPIGPNDTAISGHAIAAGAILVTNNTREFERVPGLILEDWAG

Download         Length: 417 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8678.80 Da        Isoelectric Point: 4.6017

>AT249912 WP_256876210.1 NZ_CP099908:c16175-15945 [Escherichia albertii]
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGGSIILRPVRPTWGSFAQLEKADPDFMAEREDVISDEGRFNL

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References