Detailed information of TA system TA024991

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): abiEi-abiEii/AbiEii(toxin)
• Location: 1660300..1661932
• Replicon: chromosome
• Accession: NC_014804
• Organism: Thermococcus barophilus MP

Toxin (Protein)

• Gene name: PygT
• Uniprot ID: F0LKL1
• Locus tag: TERMP_RS09245
• Protein ID: WP_013468141.1
• Coordinates: 1660916..1661932 (+)
• Length: 339 a.a.

Antitoxin (Protein)

• Gene name: PygA
• Uniprot ID: -
• Locus tag: TERMP_RS09240
• Protein ID: WP_048159988.1
• Coordinates: 1660300..1660926 (+)
• Length: 209 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
TERMP_RS09230 (TERMP_01867)	1656248..1658752	+	2505	WP_048159825.1	Piwi domain-containing protein	-
TERMP_RS09235 (TERMP_01868)	1659406..1660173	+	768	WP_013468139.1	hypothetical protein	-
TERMP_RS09240 (TERMP_01869)	1660300..1660926	+	627	WP_048159988.1	hypothetical protein	Antitoxin
TERMP_RS09245 (TERMP_01870)	1660916..1661932	+	1017	WP_013468141.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
TERMP_RS09255 (TERMP_01871)	1662425..1663108	-	684	WP_013468142.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (49-264)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 339 a.a.
• Molecular weight: 40597.98 Da
• Isoelectric Point: 9.4274

>T24991 WP_013468141.1 NC_014804:1660916-1661932 [Thermococcus barophilus MP]
MLNNELLFKIRESERKGFANFVSKKVGIKNVDMVEWDYIIHTILKELKKDPHFRENYVFKGGTYLVKCHLGYYRFSRDLD
FAYRNSEELQEMSRSKLKKFLSEETGRIAETLNCIARDLGLEFYYRDHNDFNNHRYFSFLIGPGWFREIIAYSPAGEKIK
LEFNYAEKFAFKPKTAKAHTLLSWKKAELKVRDYEKYIEFFGNHYPIRVSAYPDKEILIEKVRAILTRREFKLRDLYDLY
KLHQVKGLKIKKYEKQIIMKVKNYISLSNNARENLLKTLEELKREDYLNVLKPEVEKDAVLIVEEFDKDKFFEFVESLRK
ELLELIESEGFAALIKEW

Nucleotide

• Length: 1017 bp

>T24991 NC_014804:1660916-1661932 [Thermococcus barophilus MP]
ATGTTGAATAATGAACTTCTCTTCAAAATCAGGGAGAGTGAGAGGAAAGGCTTTGCCAATTTTGTTTCCAAGAAGGTTGG
TATTAAAAACGTAGACATGGTTGAGTGGGACTACATTATTCACACCATCCTCAAAGAGCTTAAAAAAGACCCTCATTTTA
GAGAAAACTATGTTTTCAAAGGTGGGACATACTTGGTTAAATGTCATCTGGGCTACTACCGCTTTAGCAGGGATTTAGAT
TTTGCCTATAGAAACAGTGAAGAACTCCAAGAGATGTCAAGGAGTAAACTCAAGAAATTTCTAAGTGAAGAGACGGGAAG
AATTGCTGAAACACTGAATTGCATTGCAAGAGACTTGGGATTGGAGTTTTACTACAGAGATCATAACGACTTTAACAATC
ACCGCTACTTTAGCTTTTTGATAGGGCCTGGCTGGTTTAGAGAAATAATTGCCTATTCCCCAGCGGGAGAAAAGATAAAA
CTGGAGTTCAACTATGCTGAAAAGTTCGCATTTAAACCCAAAACAGCAAAAGCACACACTCTTCTGTCATGGAAAAAGGC
AGAATTAAAAGTTAGGGATTATGAGAAATACATTGAGTTCTTCGGGAATCATTATCCCATTAGGGTTTCAGCATATCCGG
ATAAGGAAATTTTGATTGAGAAAGTGAGGGCTATTCTAACAAGGAGAGAATTCAAACTGCGTGATTTGTATGACCTTTAC
AAACTCCATCAGGTTAAAGGGCTGAAAATTAAAAAATATGAGAAGCAAATAATAATGAAGGTGAAGAATTACATCAGCCT
AAGCAACAATGCACGTGAGAACCTCTTGAAGACCCTTGAAGAACTCAAGCGAGAGGACTACTTGAATGTGCTCAAGCCAG
AAGTTGAAAAAGATGCTGTCCTTATTGTTGAAGAATTTGACAAGGATAAGTTCTTTGAGTTTGTAGAATCTCTCAGGAAA
GAATTGCTGGAATTAATTGAATCAGAAGGATTTGCAGCCCTCATTAAAGAGTGGTAA

Antitoxin

Protein

• Length: 209 a.a.
• Molecular weight: 24496.71 Da
• Isoelectric Point: 9.6961

>AT24991 WP_048159988.1 NC_014804:1660300-1660926 [Thermococcus barophilus MP]
MRSITQILLAEFGGKVITKEELEKFSTYLKVNDVDYLVNYLIQYGYIIRILRGLYYVKTPIEFSFKSSPTIYKLLSLGMN
KITKNWYFGLFTALVLNGLTHEHYTTIFIINDKIARTKIIHINGTPVRIIKTKRELFNFGIIEKDDMKISDLEKTLLDFL
YFGNYGTISKELALRIWREYKDSADWKKLKKYLEKYPESIAKVVDDVE

Nucleotide

• Length: 627 bp

>AT24991 NC_014804:1660300-1660926 [Thermococcus barophilus MP]
ATGAGATCAATTACCCAAATACTCCTGGCTGAATTTGGGGGCAAAGTCATTACAAAGGAAGAGCTGGAAAAGTTTTCCAC
TTATTTGAAAGTAAATGATGTAGATTACCTCGTAAACTATCTCATTCAGTATGGCTACATCATAAGAATTCTAAGGGGAC
TCTATTATGTTAAAACTCCCATTGAATTCTCTTTTAAGAGCTCTCCCACAATTTACAAACTCCTCTCATTGGGGATGAAT
AAGATAACGAAAAACTGGTACTTTGGCCTCTTCACAGCATTAGTTCTAAATGGATTAACTCACGAGCACTACACTACAAT
CTTCATAATCAACGACAAGATCGCAAGGACAAAAATCATTCACATAAATGGAACTCCCGTCAGAATAATCAAAACCAAAA
GAGAGCTATTTAACTTTGGAATAATCGAAAAAGATGACATGAAAATTTCTGATTTAGAAAAAACACTTTTAGATTTCCTC
TACTTTGGAAACTATGGGACAATTTCAAAAGAACTGGCTTTAAGAATCTGGAGGGAATACAAAGATAGTGCAGATTGGAA
GAAGTTGAAGAAGTATTTGGAGAAATATCCGGAGTCCATTGCAAAGGTGGTTGATGATGTTGAATAA

Structures

Toxin

• AlphaFold DB: F0LKL1