Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3545136..3545754 Replicon chromosome
Accession NZ_CP099907
Organism Escherichia albertii strain 112_1_EW_A

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag NIY89_RS17405 Protein ID WP_001280991.1
Coordinates 3545536..3545754 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID B1EKM5
Locus tag NIY89_RS17400 Protein ID WP_000344798.1
Coordinates 3545136..3545510 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NIY89_RS17390 (3540216) 3540216..3541409 + 1194 WP_010334435.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
NIY89_RS17395 (3541432) 3541432..3544581 + 3150 WP_001132500.1 efflux RND transporter permease AcrB -
NIY89_RS17400 (3545136) 3545136..3545510 + 375 WP_000344798.1 Hha toxicity modulator TomB Antitoxin
NIY89_RS17405 (3545536) 3545536..3545754 + 219 WP_001280991.1 HHA domain-containing protein Toxin
NIY89_RS17410 (3545931) 3545931..3546488 + 558 WP_000093561.1 maltose O-acetyltransferase -
NIY89_RS17415 (3546596) 3546596..3547066 + 471 WP_059224581.1 YlaC family protein -
NIY89_RS17420 (3547230) 3547230..3548780 + 1551 WP_256876043.1 EAL domain-containing protein -
NIY89_RS17425 (3548818) 3548818..3549171 - 354 WP_000878151.1 DUF1428 family protein -
NIY89_RS17435 (3549552) 3549552..3549863 + 312 WP_000409915.1 MGMT family protein -
NIY89_RS17440 (3549893) 3549893..3550465 - 573 WP_000779847.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T249903 WP_001280991.1 NZ_CP099907:3545536-3545754 [Escherichia albertii]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14499.35 Da        Isoelectric Point: 4.8989

>AT249903 WP_000344798.1 NZ_CP099907:3545136-3545510 [Escherichia albertii]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKANPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A2T3RX90

References