Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/PRK09812-MazE
Location 1963541..1964131 Replicon chromosome
Accession NZ_CP099907
Organism Escherichia albertii strain 112_1_EW_A

Toxin (Protein)


Gene name pemK Uniprot ID -
Locus tag NIY89_RS09510 Protein ID WP_059225520.1
Coordinates 1963799..1964131 (+) Length 111 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID -
Locus tag NIY89_RS09505 Protein ID WP_059225519.1
Coordinates 1963541..1963798 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NIY89_RS09495 (1962521) 1962521..1962991 + 471 WP_059225518.1 hypothetical protein -
NIY89_RS09500 (1962988) 1962988..1963193 + 206 Protein_1857 helix-turn-helix domain-containing protein -
NIY89_RS09505 (1963541) 1963541..1963798 + 258 WP_059225519.1 hypothetical protein Antitoxin
NIY89_RS09510 (1963799) 1963799..1964131 + 333 WP_059225520.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
NIY89_RS09515 (1964244) 1964244..1964621 + 378 WP_161537949.1 hypothetical protein -
NIY89_RS09520 (1964939) 1964939..1965823 + 885 WP_059225521.1 integrase domain-containing protein -
NIY89_RS09525 (1965919) 1965919..1966206 - 288 WP_059225522.1 hypothetical protein -
NIY89_RS09530 (1967165) 1967165..1968427 - 1263 WP_059225524.1 integrase arm-type DNA-binding domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-108)

Antitoxin

Antitoxin PemI-like

(4-85)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 11777.59 Da        Isoelectric Point: 8.0291

>T249893 WP_059225520.1 NZ_CP099907:1963799-1964131 [Escherichia albertii]
MDRGEIWLVSLDPIAGHEQSGKRPVLIVSPASFNEVTRLPVIVPVTSGGQFARSAGFAVSLEGAGTKTTGIIRCDQPRTI
DMGARNGKRLERIPDGIINEVLARLETILA

Download         Length: 333 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9314.80 Da        Isoelectric Point: 4.4488

>AT249893 WP_059225519.1 NZ_CP099907:1963541-1963798 [Escherichia albertii]
MYTTRLKKVGGSVMLAVPPAVLKTLALLPDSEVGVTIDNGCLIIEPQKRPRYSLAELLAQCDPHEEISDEEREWIDAPAA
GKEIL

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References