Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/DUF1778(antitoxin)
Location 298162..298962 Replicon chromosome
Accession NZ_CP099907
Organism Escherichia albertii strain 112_1_EW_A

Toxin (Protein)


Gene name ataT Uniprot ID -
Locus tag NIY89_RS01385 Protein ID WP_059225129.1
Coordinates 298435..298962 (+) Length 176 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID B1EHP0
Locus tag NIY89_RS01380 Protein ID WP_001277106.1
Coordinates 298162..298428 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NIY89_RS01360 (293819) 293819..294487 + 669 WP_000617720.1 cell division ATP-binding protein FtsE -
NIY89_RS01365 (294480) 294480..295538 + 1059 WP_001042000.1 permease-like cell division protein FtsX -
NIY89_RS01370 (295783) 295783..296637 + 855 WP_000130217.1 RNA polymerase sigma factor RpoH -
NIY89_RS01375 (296909) 296909..298012 + 1104 WP_072248450.1 branched chain amino acid ABC transporter substrate-binding protein LivJ -
NIY89_RS01380 (298162) 298162..298428 + 267 WP_001277106.1 type II toxin-antitoxin system antitoxin AtaR Antitoxin
NIY89_RS01385 (298435) 298435..298962 + 528 WP_059225129.1 type II toxin-antitoxin system toxin acetyltransferase AtaT Toxin
NIY89_RS01390 (298959) 298959..299342 - 384 WP_000778776.1 aspartate 1-decarboxylase autocleavage activator PanM -
NIY89_RS01395 (299766) 299766..300875 + 1110 Protein_275 high-affinity branched-chain amino acid ABC transporter substrate-binding protein LivK -
NIY89_RS01400 (300923) 300923..301849 + 927 WP_001295097.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
NIY89_RS01405 (301846) 301846..303123 + 1278 WP_256877739.1 branched chain amino acid ABC transporter permease LivM -
NIY89_RS01410 (303120) 303120..303887 + 768 WP_044709901.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(88-150)

Antitoxin

Vibrio phage ICP1, Orf50

(8-86)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19690.60 Da        Isoelectric Point: 6.9585

>T249890 WP_059225129.1 NZ_CP099907:298435-298962 [Escherichia albertii]
MDDLTIEILTDDADYDLQRFDCGEEALNLFLTTHLVRQHRNKILRAYILCRNTPERQVLGYYTLSGSCFERAALPSKSKQ
KKIPYKNIPSVTLGRLAIDRSLQGQGWGATLIAHAMKVVWSASLAVGIHGLFVEALNEKAHTFYQSLGFIPLVGENENAL
FFPTKSIELLFTQSD

Download         Length: 528 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9942.37 Da        Isoelectric Point: 10.0863

>AT249890 WP_001277106.1 NZ_CP099907:298162-298428 [Escherichia albertii]
MSAVKKQRIDLRLTDDDKSMIEEAAAISNQSVSQFMLNSASQRAAEVIEQHRRMILNEESWTRVMDALSNPPSPGEKLKR
AAKRLQGM

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A7Z8E004

References