Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4368351..4368969 Replicon chromosome
Accession NZ_CP099906
Organism Escherichia albertii strain 121_1_EW_A

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag NIY90_RS21055 Protein ID WP_001280991.1
Coordinates 4368351..4368569 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID B1EKM5
Locus tag NIY90_RS21060 Protein ID WP_000344798.1
Coordinates 4368595..4368969 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NIY90_RS21020 (4363641) 4363641..4364213 + 573 WP_000779847.1 YbaY family lipoprotein -
NIY90_RS21025 (4364243) 4364243..4364554 - 312 WP_000409915.1 MGMT family protein -
NIY90_RS21035 (4364935) 4364935..4365288 + 354 WP_000878151.1 DUF1428 family protein -
NIY90_RS21040 (4365326) 4365326..4366876 - 1551 WP_001260378.1 EAL domain-containing protein -
NIY90_RS21045 (4367040) 4367040..4367510 - 471 WP_059224581.1 YlaC family protein -
NIY90_RS21050 (4367617) 4367617..4368174 - 558 WP_025237467.1 maltose O-acetyltransferase -
NIY90_RS21055 (4368351) 4368351..4368569 - 219 WP_001280991.1 HHA domain-containing protein Toxin
NIY90_RS21060 (4368595) 4368595..4368969 - 375 WP_000344798.1 Hha toxicity modulator TomB Antitoxin
NIY90_RS21065 (4369524) 4369524..4372673 - 3150 WP_001132500.1 efflux RND transporter permease AcrB -
NIY90_RS21070 (4372696) 4372696..4373889 - 1194 WP_010334435.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T249888 WP_001280991.1 NZ_CP099906:c4368569-4368351 [Escherichia albertii]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14499.35 Da        Isoelectric Point: 4.8989

>AT249888 WP_000344798.1 NZ_CP099906:c4368969-4368595 [Escherichia albertii]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKANPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A2T3RX90

References