Detailed information of TA system TA024988

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/MazF(antitoxin)
• Location: 2104230..2104789
• Replicon: chromosome
• Accession: NC_014759
• Organism: Marivirga tractuosa DSM 4126

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: E4TRM0
• Locus tag: FTRAC_RS08810
• Protein ID: WP_013453888.1
• Coordinates: 2104544..2104789 (-)
• Length: 82 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: E4TRL9
• Locus tag: FTRAC_RS08805
• Protein ID: WP_013453887.1
• Coordinates: 2104230..2104553 (-)
• Length: 108 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FTRAC_RS08780	2099404..2099634	+	231	WP_013453882.1	cytochrome b5	-
FTRAC_RS08785	2099623..2100819	-	1197	WP_148230059.1	Na/Pi symporter	-
FTRAC_RS08790	2101101..2102240	+	1140	WP_013453884.1	hypothetical protein	-
FTRAC_RS08795	2102653..2103336	-	684	WP_013453885.1	hypothetical protein	-
FTRAC_RS08805	2104230..2104553	-	324	WP_013453887.1	type II toxin-antitoxin system PemK/MazF family toxin	Antitoxin
FTRAC_RS08810	2104544..2104789	-	246	WP_013453888.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Toxin
FTRAC_RS08820	2105455..2107242	-	1788	WP_013453890.1	hypothetical protein	-
FTRAC_RS08825	2107455..2108648	-	1194	WP_013453891.1	amidohydrolase	-
FTRAC_RS19275	2108907..2109416	-	510	WP_013453892.1	SPOR domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• mRNA interferase PemK-like (5-104)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9472.92 Da
• Isoelectric Point: 6.3647

>T24988 WP_013453888.1 NC_014759:c2104789-2104544 [Marivirga tractuosa DSM 4126]
MEVSVVQIGNSKGIRFSKTILEKYNIKDKVDLILEKGQIIIKPLSKPRKGWEKAFKEMSDNKDDSLLFNDVFEDENLNEW
K

Nucleotide

• Length: 246 bp

>T24988 NC_014759:c2104789-2104544 [Marivirga tractuosa DSM 4126]
ATGGAAGTTTCGGTTGTACAGATAGGAAATTCTAAAGGAATAAGATTTAGTAAGACTATTTTAGAGAAATATAATATTAA
AGATAAGGTTGATCTGATTCTAGAAAAAGGCCAAATCATCATAAAGCCTCTTTCAAAACCTCGAAAAGGGTGGGAAAAGG
CATTTAAGGAAATGTCTGACAATAAGGATGACAGTTTACTATTTAACGATGTGTTCGAGGATGAAAACCTAAACGAATGG
AAATAA

Antitoxin

Protein

• Length: 108 a.a.
• Molecular weight: 12426.58 Da
• Isoelectric Point: 9.8104

>AT24988 WP_013453887.1 NC_014759:c2104553-2104230 [Marivirga tractuosa DSM 4126]
MEINQYEIVLVNLNPTIGSEIQKTRPCVVISPNEMNKYLRTIVIAPMTTSSKNYPTRVEVKHDNKMGWIVLDQIRTVDKQ
RIIKTLDRLSKPEIKEVKSIIKETFVD

Nucleotide

• Length: 324 bp

>AT24988 NC_014759:c2104553-2104230 [Marivirga tractuosa DSM 4126]
ATGGAAATAAATCAGTACGAAATCGTTTTAGTCAATTTAAATCCTACAATCGGCAGTGAAATCCAAAAAACTAGACCTTG
CGTTGTGATTTCTCCAAACGAGATGAATAAATACCTAAGGACGATCGTGATTGCTCCCATGACAACGAGCTCAAAAAATT
ATCCCACACGAGTAGAAGTAAAACACGATAACAAAATGGGTTGGATTGTGCTCGATCAGATCAGAACTGTTGATAAGCAA
AGAATTATAAAAACTCTCGATCGGCTGTCAAAACCAGAGATAAAAGAAGTTAAAAGCATAATAAAGGAAACTTTTGTAGA
TTAA

Structures

Toxin

• AlphaFold DB: E4TRM0

Antitoxin

• AlphaFold DB: E4TRL9