Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/DUF1778(antitoxin)
Location 2797367..2798167 Replicon chromosome
Accession NZ_CP099906
Organism Escherichia albertii strain 121_1_EW_A

Toxin (Protein)


Gene name ataT Uniprot ID B1EHN9
Locus tag NIY90_RS13700 Protein ID WP_000342453.1
Coordinates 2797367..2797894 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID B1EHP0
Locus tag NIY90_RS13705 Protein ID WP_001277106.1
Coordinates 2797901..2798167 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NIY90_RS13675 (2792442) 2792442..2793209 - 768 WP_000082101.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -
NIY90_RS13680 (2793206) 2793206..2794483 - 1278 WP_256879194.1 branched chain amino acid ABC transporter permease LivM -
NIY90_RS13685 (2794480) 2794480..2795406 - 927 WP_001295111.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
NIY90_RS13690 (2795454) 2795454..2796563 - 1110 WP_256879195.1 high-affinity branched-chain amino acid ABC transporter substrate-binding protein LivK -
NIY90_RS13695 (2796987) 2796987..2797370 + 384 WP_000778774.1 aspartate 1-decarboxylase autocleavage activator PanM -
NIY90_RS13700 (2797367) 2797367..2797894 - 528 WP_000342453.1 type II toxin-antitoxin system toxin acetyltransferase AtaT Toxin
NIY90_RS13705 (2797901) 2797901..2798167 - 267 WP_001277106.1 type II toxin-antitoxin system antitoxin AtaR Antitoxin
NIY90_RS13710 (2798317) 2798317..2799420 - 1104 WP_010319184.1 branched chain amino acid ABC transporter substrate-binding protein LivJ -
NIY90_RS13715 (2799943) 2799943..2800344 + 402 WP_001071334.1 PTS sugar transporter subunit IIA -
NIY90_RS13720 (2800351) 2800351..2800836 + 486 WP_000029259.1 PTS sugar transporter subunit IIB -
NIY90_RS13725 (2800853) 2800853..2801599 + 747 WP_000151888.1 PTS sugar transporter subunit IIC -
NIY90_RS13730 (2801592) 2801592..2802446 + 855 WP_000370584.1 PTS system mannose/fructose/sorbose family transporter subunit IID -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(88-150)

Antitoxin

Vibrio phage ICP1, Orf50

(8-86)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19676.58 Da        Isoelectric Point: 6.9585

>T249879 WP_000342453.1 NZ_CP099906:c2797894-2797367 [Escherichia albertii]
MDDLTIEILTDDADYDLQRFDCGEEALNLFLTTHLVRQHRNKILRAYILCRNTPERQVLGYYTLSGSCFERAALPSKSKQ
KKIPYKNIPSVTLGRLAIDRSLQGQGWGATLVAHAMKVVWSASLAVGIHGLFVEALNEKAHTFYQSLGFIPLVGENENAL
FFPTKSIELLFTQSD

Download         Length: 528 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9942.37 Da        Isoelectric Point: 10.0863

>AT249879 WP_001277106.1 NZ_CP099906:c2798167-2797901 [Escherichia albertii]
MSAVKKQRIDLRLTDDDKSMIEEAAAISNQSVSQFMLNSASQRAAEVIEQHRRMILNEESWTRVMDALSNPPSPGEKLKR
AAKRLQGM

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A7Z8E004

References