Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 64625..65268 Replicon plasmid plas2
Accession NZ_CP099905
Organism Escherichia albertii strain 133_1_GWG_A

Toxin (Protein)


Gene name vagD Uniprot ID -
Locus tag NIY95_RS24840 Protein ID WP_256876211.1
Coordinates 64625..65041 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID -
Locus tag NIY95_RS24845 Protein ID WP_256876210.1
Coordinates 65038..65268 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NIY95_RS24815 (59676) 59676..60017 - 342 Protein_62 protein RepA -
NIY95_RS24820 (60554) 60554..61150 - 597 WP_256876215.1 hypothetical protein -
NIY95_RS24825 (61138) 61138..61407 - 270 WP_256876214.1 hypothetical protein -
NIY95_RS24830 (61726) 61726..63297 + 1572 WP_256876213.1 ATP-binding protein -
NIY95_RS24835 (63505) 63505..64485 - 981 WP_256876212.1 hypothetical protein -
NIY95_RS24840 (64625) 64625..65041 - 417 WP_256876211.1 type II toxin-antitoxin system VapC family toxin Toxin
NIY95_RS24845 (65038) 65038..65268 - 231 WP_256876210.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
NIY95_RS24850 (65837) 65837..66250 + 414 WP_000465043.1 hypothetical protein -
NIY95_RS24855 (66252) 66252..67034 + 783 WP_021533580.1 site-specific integrase -
NIY95_RS24860 (67207) 67207..67560 + 354 WP_000864812.1 colicin M immunity protein -
NIY95_RS24865 (67610) 67610..68425 - 816 WP_000449473.1 lipid II-degrading bacteriocin colicin M -
NIY95_RS24870 (68668) 68668..69195 + 528 WP_000203268.1 colicin B immunity protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - espL2 1..89077 89077


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-49)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15080.41 Da        Isoelectric Point: 6.7125

>T249864 WP_256876211.1 NZ_CP099905:c65041-64625 [Escherichia albertii]
VNKIYMLDTNICSFIMREQPEAVLKRLEQAVLRGHRIVVSAITYSEMRFGATGPKASPRHVQLVDAFCERLDAVLPWDRA
AVDATTEIKVALRLAGTPIGPNDTAISGHAIAAGAILVTNNTREFERVPGLILEDWAG

Download         Length: 417 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8678.80 Da        Isoelectric Point: 4.6017

>AT249864 WP_256876210.1 NZ_CP099905:c65268-65038 [Escherichia albertii]
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGGSIILRPVRPTWGSFAQLEKADPDFMAEREDVISDEGRFNL

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References