Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-Phd
Location 77156..77757 Replicon plasmid plas1
Accession NZ_CP099904
Organism Escherichia albertii strain 133_1_GWG_A

Toxin (Protein)


Gene name doc Uniprot ID U9YA20
Locus tag NIY95_RS24220 Protein ID WP_001216045.1
Coordinates 77377..77757 (+) Length 127 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID U9YQH9
Locus tag NIY95_RS24215 Protein ID WP_001190712.1
Coordinates 77156..77377 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NIY95_RS24205 (NIY95_24175) 74194..75420 - 1227 WP_256876192.1 restriction endonuclease subunit S -
NIY95_RS24210 (NIY95_24180) 75417..76973 - 1557 WP_073511017.1 type I restriction-modification system subunit M -
NIY95_RS24215 (NIY95_24185) 77156..77377 + 222 WP_001190712.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
NIY95_RS24220 (NIY95_24190) 77377..77757 + 381 WP_001216045.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
NIY95_RS24225 (NIY95_24195) 77762..77941 + 180 WP_000113019.1 hypothetical protein -
NIY95_RS24230 (NIY95_24200) 77969..79012 + 1044 WP_256876191.1 DUF968 domain-containing protein -
NIY95_RS24235 (NIY95_24205) 79101..79553 + 453 WP_001326849.1 late promoter-activating protein -
NIY95_RS24240 (NIY95_24210) 79640..80833 + 1194 WP_000219618.1 hypothetical protein -
NIY95_RS24245 (NIY95_24215) 80833..82317 + 1485 WP_000124159.1 hypothetical protein -
NIY95_RS24250 (NIY95_24220) 82401..82631 + 231 Protein_81 ash family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..132627 132627


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(3-120)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-51)


Sequences

Toxin        


Download         Length: 127 a.a.        Molecular weight: 13588.29 Da        Isoelectric Point: 5.1514

>T249863 WP_001216045.1 NZ_CP099904:77377-77757 [Escherichia albertii]
MRHISPEELIALHDANISRYGGLPGMSDPGRAEAIIGRVQARVAYEEITDLFEVSATYLVATARGHIFNDANKRTALNSA
LLFLRRNGVQVFDSPELADLTVGAATGEISVSSVADTLRRLYGSAE

Download         Length: 381 bp

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8133.10 Da        Isoelectric Point: 4.7708

>AT249863 WP_001190712.1 NZ_CP099904:77156-77377 [Escherichia albertii]
MQSINFRTARGNLSEVLNNVEAGEEVEITRRGREPAVIVSKATFEAYKKAALDAEFASLFDTLDSTNKELVNR

Download         Length: 222 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CLP7

Antitoxin

Source ID Structure
AlphaFold DB A0A829CJB6

References