Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3536008..3536626 Replicon chromosome
Accession NZ_CP099903
Organism Escherichia albertii strain 133_1_GWG_A

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag NIY95_RS17285 Protein ID WP_001280991.1
Coordinates 3536408..3536626 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID B1EKM5
Locus tag NIY95_RS17280 Protein ID WP_000344798.1
Coordinates 3536008..3536382 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NIY95_RS17270 (3531088) 3531088..3532281 + 1194 WP_010334435.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
NIY95_RS17275 (3532304) 3532304..3535453 + 3150 WP_001132500.1 efflux RND transporter permease AcrB -
NIY95_RS17280 (3536008) 3536008..3536382 + 375 WP_000344798.1 Hha toxicity modulator TomB Antitoxin
NIY95_RS17285 (3536408) 3536408..3536626 + 219 WP_001280991.1 HHA domain-containing protein Toxin
NIY95_RS17290 (3536803) 3536803..3537360 + 558 WP_000093561.1 maltose O-acetyltransferase -
NIY95_RS17295 (3537468) 3537468..3537938 + 471 WP_059224581.1 YlaC family protein -
NIY95_RS17300 (3538102) 3538102..3539652 + 1551 WP_256876043.1 EAL domain-containing protein -
NIY95_RS17305 (3539690) 3539690..3540043 - 354 WP_000878151.1 DUF1428 family protein -
NIY95_RS17315 (3540424) 3540424..3540735 + 312 WP_000409915.1 MGMT family protein -
NIY95_RS17320 (3540765) 3540765..3541337 - 573 WP_000779847.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T249854 WP_001280991.1 NZ_CP099903:3536408-3536626 [Escherichia albertii]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14499.35 Da        Isoelectric Point: 4.8989

>AT249854 WP_000344798.1 NZ_CP099903:3536008-3536382 [Escherichia albertii]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKANPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A2T3RX90

References