Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 1366639..1367294 Replicon chromosome
Accession NC_014752
Organism Neisseria lactamica 020-06

Toxin (Protein)


Gene name vapC Uniprot ID E4ZDN8
Locus tag NLA_RS06525 Protein ID WP_013449085.1
Coordinates 1366639..1367058 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID E4ZDN9
Locus tag NLA_RS06530 Protein ID WP_003712357.1
Coordinates 1367055..1367294 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NLA_RS06505 1361872..1363278 - 1407 WP_013449083.1 MFS transporter -
NLA_RS06510 1363562..1364341 + 780 WP_013449084.1 (Fe-S)-binding protein -
NLA_RS06515 1364338..1365039 + 702 WP_003712352.1 lactate utilization protein C -
NLA_RS06520 1365036..1366490 + 1455 WP_003709031.1 iron-sulfur cluster-binding protein -
NLA_RS06525 1366639..1367058 - 420 WP_013449085.1 type II toxin-antitoxin system toxin FitB Toxin
NLA_RS06530 1367055..1367294 - 240 WP_003712357.1 hypothetical protein Antitoxin
NLA_RS13585 1367387..1367665 - 279 WP_042508221.1 hypothetical protein -
NLA_RS06540 1368107..1368592 - 486 WP_013449086.1 5-(carboxyamino)imidazole ribonucleotide mutase -
NLA_RS06545 1368641..1369357 - 717 WP_013449087.1 tol-pal system YbgF family protein -
NLA_RS06550 1369357..1370025 - 669 WP_013449088.1 O-methyltransferase -
NLA_RS06555 1370036..1370221 - 186 WP_002216929.1 DUF3460 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - kdsA / pilW 1149374..1448712 299338


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-124)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15229.63 Da        Isoelectric Point: 6.0764

>T24985 WP_013449085.1 NC_014752:c1367058-1366639 [Neisseria lactamica 020-06]
MILLDTNVISEPLRPQPNERVVAWLDSLILEDVYLSAITVAELRLGVALLPDGKKKNVLHERLEQSILPLFAGRILPFDE
PVAAIYAQIHSYAKTHGKAIAAADGYIAATAKQHRLAVATRDTGPFFAADVAVFNPWCD

Download         Length: 420 bp

>T24985 NC_014752:c1367058-1366639 [Neisseria lactamica 020-06]
ATGATTTTACTGGATACGAATGTGATTTCTGAACCTTTGCGCCCACAGCCCAATGAACGTGTGGTGGCATGGTTGGATAG
TTTGATATTGGAAGATGTGTATTTGTCTGCCATTACTGTTGCAGAATTGCGTTTGGGTGTGGCGTTGTTGCCTGATGGTA
AGAAAAAGAATGTGCTGCACGAGCGTTTGGAACAATCCATTTTGCCTTTATTTGCGGGGCGGATTCTGCCTTTTGATGAA
CCGGTTGCCGCAATATATGCGCAAATTCATTCCTATGCCAAAACACATGGCAAAGCGATTGCCGCCGCAGACGGCTATAT
TGCCGCCACTGCAAAACAGCACCGTTTGGCAGTTGCTACGCGTGATACCGGTCCATTTTTTGCGGCCGATGTCGCGGTGT
TCAATCCGTGGTGCGATTAA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8673.83 Da        Isoelectric Point: 8.9167

>AT24985 WP_003712357.1 NC_014752:c1367294-1367055 [Neisseria lactamica 020-06]
MASVVIRNLSETTHNAIKFRARAAGRSTEAEIRLILDNIAKAQQTVRLGSMLASIGQEVDGVELDNVRDFDTKNRVSFG

Download         Length: 240 bp

>AT24985 NC_014752:c1367294-1367055 [Neisseria lactamica 020-06]
ATGGCTTCTGTTGTGATTAGAAATTTATCCGAGACCACGCACAACGCAATCAAATTCCGCGCGCGAGCCGCAGGGCGCAG
TACCGAAGCGGAAATCCGCTTAATTTTGGATAACATCGCCAAAGCACAGCAAACGGTACGTTTGGGGTCAATGTTGGCAT
CAATAGGGCAGGAAGTGGATGGTGTGGAGTTGGATAACGTGCGTGATTTCGATACCAAGAACAGGGTATCCTTTGGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A378VEW5

Antitoxin

Source ID Structure
AlphaFold DB A0A1V0DVG7

References