Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) VapXD/-
Location 938335..938798 Replicon chromosome
Accession NC_014752
Organism Neisseria lactamica 020-06

Toxin (Protein)


Gene name VapD Uniprot ID E4ZCN5
Locus tag NLA_RS04680 Protein ID WP_013448818.1
Coordinates 938520..938798 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name VapX Uniprot ID Q51002
Locus tag NLA_RS04675 Protein ID WP_003690223.1
Coordinates 938335..938520 (+) Length 62 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NLA_RS04660 934338..935567 - 1230 WP_013448814.1 ATP-binding protein -
NLA_RS11390 936340..936733 - 394 Protein_912 transposase -
NLA_RS04670 937600..938037 + 438 WP_013448817.1 virulence-associated protein VapD -
NLA_RS04675 938335..938520 + 186 WP_003690223.1 DUF5397 family protein Antitoxin
NLA_RS04680 938520..938798 + 279 WP_013448818.1 virulence factor Toxin

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Virulence-associated protein D / CRISPR associated protein Cas2

(1-86)

Antitoxin

Protein of unknown function DUF5397

(2-60)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10440.81 Da        Isoelectric Point: 6.4481

>T24984 WP_013448818.1 NC_014752:938520-938798 [Neisseria lactamica 020-06]
MYAISFDLVVADTAQNHPKGISQAYADIGYTLRKFGFTHVQGSLYTCQNEDMANLFSAINELKALPWFPSSVRDIRAFRI
EQWSDFTSLVKS

Download         Length: 279 bp

>T24984 NC_014752:938520-938798 [Neisseria lactamica 020-06]
ATGTACGCGATTTCTTTTGATTTGGTGGTTGCCGATACCGCTCAAAACCATCCGAAAGGCATTTCCCAAGCCTACGCGGA
TATTGGATACACCCTGCGGAAATTCGGCTTTACCCACGTTCAGGGAAGTTTGTACACCTGCCAAAACGAAGATATGGCTA
ACCTGTTTTCAGCCATCAACGAGCTAAAAGCTCTGCCTTGGTTTCCGTCTTCTGTCCGCGATATTCGGGCGTTCCGCATT
GAGCAGTGGTCCGATTTCACAAGTCTTGTGAAGTCTTAA

Antitoxin


Download         Length: 62 a.a.        Molecular weight: 6717.54 Da        Isoelectric Point: 4.2641

>AT24984 WP_003690223.1 NC_014752:938335-938520 [Neisseria lactamica 020-06]
MQTTIPTGSIRTFGDYGVMYIVGTPAEQLPDGDWLVNIELPESGEHTQYKLSHIVQDPKAA

Download         Length: 186 bp

>AT24984 NC_014752:938335-938520 [Neisseria lactamica 020-06]
ATGCAAACCACTATCCCCACCGGTTCAATCCGCACCTTTGGCGATTACGGCGTGATGTACATCGTCGGCACGCCTGCTGA
ACAGCTTCCTGACGGCGATTGGCTCGTAAATATCGAGCTGCCGGAAAGCGGCGAACACACGCAATACAAACTGTCCCACA
TCGTTCAAGACCCAAAGGCTGCCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB E4ZCN5

Antitoxin

Source ID Structure
AlphaFold DB Q51002

References