Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3431625..3432243 Replicon chromosome
Accession NZ_CP099898
Organism Escherichia albertii strain 147_1_TBG_A

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag NIZ13_RS16825 Protein ID WP_001280991.1
Coordinates 3432025..3432243 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID B1EKM5
Locus tag NIZ13_RS16820 Protein ID WP_000344798.1
Coordinates 3431625..3431999 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NIZ13_RS16810 (3426705) 3426705..3427898 + 1194 WP_010334435.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
NIZ13_RS16815 (3427921) 3427921..3431070 + 3150 WP_001132500.1 efflux RND transporter permease AcrB -
NIZ13_RS16820 (3431625) 3431625..3431999 + 375 WP_000344798.1 Hha toxicity modulator TomB Antitoxin
NIZ13_RS16825 (3432025) 3432025..3432243 + 219 WP_001280991.1 HHA domain-containing protein Toxin
NIZ13_RS16830 (3432420) 3432420..3432977 + 558 WP_025237467.1 maltose O-acetyltransferase -
NIZ13_RS16835 (3433084) 3433084..3433554 + 471 WP_000136188.1 YlaC family protein -
NIZ13_RS16840 (3433718) 3433718..3435268 + 1551 WP_059234326.1 EAL domain-containing protein -
NIZ13_RS16845 (3435306) 3435306..3435659 - 354 WP_000878151.1 DUF1428 family protein -
NIZ13_RS16855 (3436040) 3436040..3436351 + 312 WP_000409915.1 MGMT family protein -
NIZ13_RS16860 (3436381) 3436381..3436953 - 573 WP_256875765.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T249828 WP_001280991.1 NZ_CP099898:3432025-3432243 [Escherichia albertii]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14499.35 Da        Isoelectric Point: 4.8989

>AT249828 WP_000344798.1 NZ_CP099898:3431625-3431999 [Escherichia albertii]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKANPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A2T3RX90

References