Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/DUF1778(antitoxin)
Location 297802..298602 Replicon chromosome
Accession NZ_CP099898
Organism Escherichia albertii strain 147_1_TBG_A

Toxin (Protein)


Gene name ataT Uniprot ID A0A8H9C5V7
Locus tag NIZ13_RS01375 Protein ID WP_000342455.1
Coordinates 298075..298602 (+) Length 176 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID B1EHP0
Locus tag NIZ13_RS01370 Protein ID WP_001277106.1
Coordinates 297802..298068 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NIZ13_RS01350 (293398) 293398..294456 + 1059 WP_001042000.1 permease-like cell division protein FtsX -
NIZ13_RS01355 (294701) 294701..295555 + 855 WP_000130217.1 RNA polymerase sigma factor RpoH -
NIZ13_RS01360 (295752) 295752..296261 + 510 WP_059235675.1 hypothetical protein -
NIZ13_RS01365 (296549) 296549..297652 + 1104 WP_010319184.1 branched chain amino acid ABC transporter substrate-binding protein LivJ -
NIZ13_RS01370 (297802) 297802..298068 + 267 WP_001277106.1 type II toxin-antitoxin system antitoxin AtaR Antitoxin
NIZ13_RS01375 (298075) 298075..298602 + 528 WP_000342455.1 type II toxin-antitoxin system toxin acetyltransferase AtaT Toxin
NIZ13_RS01380 (298599) 298599..298982 - 384 WP_059235673.1 aspartate 1-decarboxylase autocleavage activator PanM -
NIZ13_RS01385 (299406) 299406..300515 + 1110 WP_256875830.1 high-affinity branched-chain amino acid ABC transporter substrate-binding protein LivK -
NIZ13_RS01390 (300563) 300563..301489 + 927 WP_001295111.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
NIZ13_RS01395 (301486) 301486..302763 + 1278 WP_044709902.1 branched chain amino acid ABC transporter permease LivM -
NIZ13_RS01400 (302760) 302760..303527 + 768 WP_044709901.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(90-150)

Antitoxin

Vibrio phage ICP1, Orf50

(8-86)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19607.47 Da        Isoelectric Point: 6.6343

>T249817 WP_000342455.1 NZ_CP099898:298075-298602 [Escherichia albertii]
MDDLTIEILTDDADYDLQRFDCGEEALNLFLTTHLVRQHRNKILRAYILCSNTPERQVLGYYTLSGSCFERAALPSKSKQ
KKIPYKNIPSVTLGRLAIDRSLQGQGWGATLVAHAMKVVWSASLAVGIHGLFVEALNEKAHTFYQSLGFIPLVGENENAL
FFPTKSIELLFTQSD

Download         Length: 528 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9942.37 Da        Isoelectric Point: 10.0863

>AT249817 WP_001277106.1 NZ_CP099898:297802-298068 [Escherichia albertii]
MSAVKKQRIDLRLTDDDKSMIEEAAAISNQSVSQFMLNSASQRAAEVIEQHRRMILNEESWTRVMDALSNPPSPGEKLKR
AAKRLQGM

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A7Z8E004

References