Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataT-KacA/DUF1778(antitoxin)
Location 110678..111476 Replicon plasmid plas1
Accession NZ_CP099896
Organism Escherichia albertii strain 153_2_TBG_A

Toxin (Protein)


Gene name ataT Uniprot ID E2QDF3
Locus tag NIZ14_RS23540 Protein ID WP_000072677.1
Coordinates 110955..111476 (+) Length 174 a.a.

Antitoxin (Protein)


Gene name KacA Uniprot ID A0A0V9R6Q7
Locus tag NIZ14_RS23535 Protein ID WP_001351987.1
Coordinates 110678..110947 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NIZ14_RS23510 (NIZ14_23495) 106106..107446 - 1341 WP_000137333.1 DnaB-like helicase C-terminal domain-containing protein -
NIZ14_RS23515 (NIZ14_23500) 107490..108230 - 741 WP_187192596.1 hypothetical protein -
NIZ14_RS23520 (NIZ14_23505) 108513..109280 + 768 WP_000342417.1 hypothetical protein -
NIZ14_RS23525 (NIZ14_23510) 109333..109685 - 353 Protein_122 hypothetical protein -
NIZ14_RS23530 (NIZ14_23515) 109691..110359 - 669 WP_000161228.1 division plane positioning ATPase MipZ -
NIZ14_RS23535 (NIZ14_23520) 110678..110947 + 270 WP_001351987.1 DUF1778 domain-containing protein Antitoxin
NIZ14_RS23540 (NIZ14_23525) 110955..111476 + 522 WP_000072677.1 GNAT family N-acetyltransferase Toxin
NIZ14_RS23545 (NIZ14_23530) 111645..111896 - 252 WP_000901559.1 hypothetical protein -
NIZ14_RS23550 (NIZ14_23535) 111898..112590 - 693 WP_000856757.1 hypothetical protein -
NIZ14_RS23555 (NIZ14_23540) 112604..112927 - 324 WP_001717323.1 hypothetical protein -
NIZ14_RS23560 (NIZ14_23545) 113130..115673 - 2544 WP_256880912.1 tail fiber protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..124502 124502


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(72-150)

Antitoxin

Vibrio phage ICP1, Orf50

(8-86)


Sequences

Toxin        


Download         Length: 174 a.a.        Molecular weight: 19392.17 Da        Isoelectric Point: 8.6369

>T249812 WP_000072677.1 NZ_CP099896:110955-111476 [Escherichia albertii]
VSNTTIEIFSGEKDYDLNGFDCGEESLNAFLANHLKRQHEGKILRAYVLCTQEERPKVLGYYTLSGSCFEKESLPSRSKQ
KKVPYRNVPSVTLGRLALDKSLQGQGFGSMLVTHAMRVVYNASLAVGIHGLFVEALNDKAKAFYKSLGFIQLVGNNERSL
FYPTKSIEKLFEE

Download         Length: 522 bp

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10082.54 Da        Isoelectric Point: 7.0155

>AT249812 WP_001351987.1 NZ_CP099896:110678-110947 [Escherichia albertii]
MSALKKQRIDLRLTDDDKSIIEEAAAMSNQSITQFMVSSASERAVKVIEQHRRLVLNEESWNLVMDAISNPPAPNDKLKR
AADRLKSME

Download         Length: 270 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0V9R6P3

Antitoxin

Source ID Structure
AlphaFold DB A0A0V9R6Q7

References