Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataT-KacA/DUF1778(antitoxin)
Location 2737..3535 Replicon plasmid plas1
Accession NZ_CP099896
Organism Escherichia albertii strain 153_2_TBG_A

Toxin (Protein)


Gene name ataT Uniprot ID E2QDF3
Locus tag NIZ14_RS22915 Protein ID WP_000072677.1
Coordinates 3014..3535 (+) Length 174 a.a.

Antitoxin (Protein)


Gene name KacA Uniprot ID A0A0V9R6Q7
Locus tag NIZ14_RS22910 Protein ID WP_001351987.1
Coordinates 2737..3006 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NIZ14_RS22895 (NIZ14_22880) 570..1338 + 769 Protein_0 hypothetical protein -
NIZ14_RS22900 (NIZ14_22885) 1391..1744 - 354 WP_160378290.1 hypothetical protein -
NIZ14_RS22905 (NIZ14_22890) 1750..2418 - 669 WP_000161228.1 division plane positioning ATPase MipZ -
NIZ14_RS22910 (NIZ14_22895) 2737..3006 + 270 WP_001351987.1 DUF1778 domain-containing protein Antitoxin
NIZ14_RS22915 (NIZ14_22900) 3014..3535 + 522 WP_000072677.1 GNAT family N-acetyltransferase Toxin
NIZ14_RS22920 (NIZ14_22905) 3704..3956 - 253 Protein_5 hypothetical protein -
NIZ14_RS22925 (NIZ14_22910) 3958..4653 - 696 WP_256880914.1 hypothetical protein -
NIZ14_RS22930 (NIZ14_22915) 4667..4990 - 324 WP_001717323.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..124502 124502


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(72-150)

Antitoxin

Vibrio phage ICP1, Orf50

(8-86)


Sequences

Toxin        


Download         Length: 174 a.a.        Molecular weight: 19392.17 Da        Isoelectric Point: 8.6369

>T249811 WP_000072677.1 NZ_CP099896:3014-3535 [Escherichia albertii]
VSNTTIEIFSGEKDYDLNGFDCGEESLNAFLANHLKRQHEGKILRAYVLCTQEERPKVLGYYTLSGSCFEKESLPSRSKQ
KKVPYRNVPSVTLGRLALDKSLQGQGFGSMLVTHAMRVVYNASLAVGIHGLFVEALNDKAKAFYKSLGFIQLVGNNERSL
FYPTKSIEKLFEE

Download         Length: 522 bp

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10082.54 Da        Isoelectric Point: 7.0155

>AT249811 WP_001351987.1 NZ_CP099896:2737-3006 [Escherichia albertii]
MSALKKQRIDLRLTDDDKSIIEEAAAMSNQSITQFMVSSASERAVKVIEQHRRLVLNEESWNLVMDAISNPPAPNDKLKR
AADRLKSME

Download         Length: 270 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0V9R6P3

Antitoxin

Source ID Structure
AlphaFold DB A0A0V9R6Q7

References