Detailed information of TA system TA024980

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): pasABC/RelE-HTH
• Location: 33133..33610
• Replicon: plasmid pBRH02
• Accession: NC_014723
• Organism: Burkholderia rhizoxinica HKI 454

Toxin (Protein)

• Gene name: pasB
• Uniprot ID: -
• Locus tag: RBRH_RS18290
• Protein ID: WP_013436667.1
• Coordinates: 33344..33610 (+)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: pasA
• Uniprot ID: -
• Locus tag: RBRH_RS15410
• Protein ID: WP_041755101.1
• Coordinates: 33133..33360 (+)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
RBRH_RS15380	28884..29912	+	1029	WP_041755097.1	chromosome partitioning protein ParB	-
RBRH_RS18275	30373..31593	+	1221	WP_157864637.1	Replication protein O	-
RBRH_RS19515	32371..32466	-	96	Protein_21	transposase	-
RBRH_RS18285	32628..33038	+	411	Protein_22	transposase	-
RBRH_RS15410	33133..33360	+	228	WP_041755101.1	ribbon-helix-helix protein, CopG family	Antitoxin
RBRH_RS18290	33344..33610	+	267	WP_013436667.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
RBRH_RS15415	34071..34325	+	255	WP_041755148.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
RBRH_RS15420	34322..34747	+	426	WP_013436669.1	type II toxin-antitoxin system VapC family toxin	-
RBRH_RS15425	34986..35276	+	291	WP_041755149.1	nucleotidyltransferase family protein	-
RBRH_RS15430	35273..35668	+	396	WP_013436671.1	DUF86 domain-containing protein	-
RBRH_RS18295	35794..35907	+	114	Protein_29	transposase	-
RBRH_RS19520	35915..36181	-	267	Protein_30	IS3 family transposase	-
RBRH_RS19525	36181..36692	-	512	Protein_31	transposase	-
RBRH_RS19530	37123..37362	+	240	WP_157864638.1	hypothetical protein	-
RBRH_RS15440	37448..37723	+	276	WP_049786588.1	hypothetical protein	-
RBRH_RS15445	37822..38091	+	270	WP_041755103.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..172525	172525
	-	flank	IS/Tn	-	-	32574..32714	140

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-87)

Antitoxin

• Protein of unknown function DUF6290 (1-71)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10151.81 Da
• Isoelectric Point: 10.1422

>T24980 WP_013436667.1 NC_014723:33344-33610 [Mycetohabitans rhizoxinica HKI 454]
MAWTIDYTDTAKGQLRKLDKPVARRIVDFMDARVASLEDPRSIGKVLTGPFGSFWRYRVGDYRVICKIQDSALCVLVVQI
GNRREVYR

Nucleotide

• Length: 267 bp

>T24980 NC_014723:33344-33610 [Mycetohabitans rhizoxinica HKI 454]
TTGGCCTGGACGATTGATTACACTGATACAGCCAAAGGACAGCTACGTAAGCTCGATAAACCCGTCGCACGACGCATCGT
TGACTTCATGGACGCGCGTGTTGCCAGTCTAGAAGACCCTCGAAGTATCGGTAAAGTACTGACTGGCCCATTCGGTAGCT
TTTGGCGTTACCGGGTGGGCGATTACCGTGTAATTTGTAAGATTCAAGATAGCGCTTTATGCGTTCTTGTAGTGCAGATC
GGTAACCGACGCGAGGTTTACCGTTAG

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8674.73 Da
• Isoelectric Point: 5.6390

>AT24980 WP_041755101.1 NC_014723:33133-33360 [Mycetohabitans rhizoxinica HKI 454]
MATSVRLSPETEQRLDHLATHTGRTKAYYLREIIDRGIEEMEDYYLAADVLERVRKGREKVHSAADVRKDLGLDD

Nucleotide

• Length: 228 bp

>AT24980 NC_014723:33133-33360 [Mycetohabitans rhizoxinica HKI 454]
ATGGCTACCTCAGTTCGTCTTTCTCCCGAAACCGAGCAACGGCTCGATCATCTAGCGACTCATACTGGGCGGACAAAGGC
ATATTACCTGCGTGAAATCATCGATCGTGGCATTGAAGAGATGGAGGACTATTACCTTGCTGCCGACGTGCTGGAACGTG
TCCGCAAGGGCCGGGAGAAAGTGCATTCCGCTGCTGACGTAAGGAAAGACCTTGGCCTGGACGATTGA