Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 2510..3045 Replicon plasmid plas2
Accession NZ_CP099894
Organism Escherichia albertii strain 155_2_TBG_A

Toxin (Protein)


Gene name relE Uniprot ID T2HS21
Locus tag NIZ16_RS23650 Protein ID WP_000222775.1
Coordinates 2758..3045 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID T2HSA2
Locus tag NIZ16_RS23645 Protein ID WP_001139207.1
Coordinates 2510..2761 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NIZ16_RS23630 (NIZ16_23615) 580..1563 + 984 Protein_1 plasmid segregation protein ParM -
NIZ16_RS23635 (NIZ16_23620) 1556..1972 + 417 WP_256875925.1 plasmid partitioning/stability family protein -
NIZ16_RS23640 (NIZ16_23625) 1974..2395 - 422 Protein_3 DUF4113 domain-containing protein -
NIZ16_RS23645 (NIZ16_23630) 2510..2761 + 252 WP_001139207.1 plasmid stabilization protein Antitoxin
NIZ16_RS23650 (NIZ16_23635) 2758..3045 + 288 WP_000222775.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NIZ16_RS23655 (NIZ16_23640) 3055..3426 + 372 WP_256875924.1 hypothetical protein -
NIZ16_RS23660 (NIZ16_23645) 4327..4913 + 587 Protein_7 serine acetyltransferase -
NIZ16_RS23665 (NIZ16_23650) 5193..5786 - 594 WP_001523457.1 ProQ/FINO family protein -
NIZ16_RS23670 (NIZ16_23655) 6791..7555 + 765 WP_256875923.1 helix-turn-helix domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - espL2 / faeH / faeI 1..79677 79677


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11142.17 Da        Isoelectric Point: 10.6261

>T249788 WP_000222775.1 NZ_CP099894:2758-3045 [Escherichia albertii]
MTYTVKFRDDALREWLKLDKSVQQQFAKKLKKCSENPHIPSAKLRGLKDCYKIKLRASGFRLVYQVIDDMLIIAVVAVGK
RERSHVYNLASERMR

Download         Length: 288 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9216.45 Da        Isoelectric Point: 4.0927

>AT249788 WP_001139207.1 NZ_CP099894:2510-2761 [Escherichia albertii]
MPSIILSDTSASVSELKKNPMATVSAGEGYPVAILNRNQPAFYCVPAELYERMLDAMDDQELVKLVTERSNQPLHDVDLD
SYL

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB T2HS21

Antitoxin

Source ID Structure
AlphaFold DB A0A754EQ65

References