Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataT-KacA/DUF1778(antitoxin)
Location 91932..92730 Replicon plasmid plas1
Accession NZ_CP099893
Organism Escherichia albertii strain 155_2_TBG_A

Toxin (Protein)


Gene name ataT Uniprot ID E2QDF3
Locus tag NIZ16_RS23465 Protein ID WP_000072677.1
Coordinates 92209..92730 (+) Length 174 a.a.

Antitoxin (Protein)


Gene name KacA Uniprot ID A0A0V9R6Q7
Locus tag NIZ16_RS23460 Protein ID WP_001351987.1
Coordinates 91932..92201 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NIZ16_RS23435 (NIZ16_23420) 87359..88699 - 1341 WP_000137333.1 DnaB-like helicase C-terminal domain-containing protein -
NIZ16_RS23440 (NIZ16_23425) 88743..89483 - 741 WP_187192596.1 hypothetical protein -
NIZ16_RS23445 (NIZ16_23430) 89766..90533 + 768 WP_000342417.1 hypothetical protein -
NIZ16_RS23450 (NIZ16_23435) 90586..90939 - 354 WP_160378290.1 hypothetical protein -
NIZ16_RS23455 (NIZ16_23440) 90945..91613 - 669 WP_000161228.1 division plane positioning ATPase MipZ -
NIZ16_RS23460 (NIZ16_23445) 91932..92201 + 270 WP_001351987.1 DUF1778 domain-containing protein Antitoxin
NIZ16_RS23465 (NIZ16_23450) 92209..92730 + 522 WP_000072677.1 GNAT family N-acetyltransferase Toxin
NIZ16_RS23470 (NIZ16_23455) 92899..93150 - 252 WP_000901559.1 hypothetical protein -
NIZ16_RS23475 (NIZ16_23460) 93152..93844 - 693 WP_012640731.1 hypothetical protein -
NIZ16_RS23480 (NIZ16_23465) 93858..94181 - 324 WP_000064175.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..126289 126289


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(72-150)

Antitoxin

Vibrio phage ICP1, Orf50

(8-86)


Sequences

Toxin        


Download         Length: 174 a.a.        Molecular weight: 19392.17 Da        Isoelectric Point: 8.6369

>T249787 WP_000072677.1 NZ_CP099893:92209-92730 [Escherichia albertii]
VSNTTIEIFSGEKDYDLNGFDCGEESLNAFLANHLKRQHEGKILRAYVLCTQEERPKVLGYYTLSGSCFEKESLPSRSKQ
KKVPYRNVPSVTLGRLALDKSLQGQGFGSMLVTHAMRVVYNASLAVGIHGLFVEALNDKAKAFYKSLGFIQLVGNNERSL
FYPTKSIEKLFEE

Download         Length: 522 bp

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10082.54 Da        Isoelectric Point: 7.0155

>AT249787 WP_001351987.1 NZ_CP099893:91932-92201 [Escherichia albertii]
MSALKKQRIDLRLTDDDKSIIEEAAAMSNQSITQFMVSSASERAVKVIEQHRRLVLNEESWNLVMDAISNPPAPNDKLKR
AADRLKSME

Download         Length: 270 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0V9R6P3

Antitoxin

Source ID Structure
AlphaFold DB A0A0V9R6Q7

References