Detailed information of TA system TA024977

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/upstrm_HI1419-dnstrm_HI1420
• Location: 1970402..1971054
• Replicon: chromosome
• Accession: NC_014722
• Organism: Burkholderia rhizoxinica HKI 454

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: RBRH_RS08595
• Protein ID: WP_041753697.1
• Coordinates: 1970402..1970698 (+)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: E5ASI0
• Locus tag: RBRH_RS08600
• Protein ID: WP_013435791.1
• Coordinates: 1970701..1971054 (+)
• Length: 118 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
RBRH_RS08565	1965524..1965976	+	453	WP_013435785.1	protein TolR	-
RBRH_RS08570	1965973..1966935	+	963	WP_013435786.1	cell envelope integrity protein TolA	-
RBRH_RS08575	1967078..1968370	+	1293	WP_013435787.1	Tol-Pal system protein TolB	-
RBRH_RS08580	1968389..1968898	+	510	WP_013435788.1	peptidoglycan-associated lipoprotein Pal	-
RBRH_RS08585	1968916..1969665	+	750	WP_013435789.1	tol-pal system protein YbgF	-
RBRH_RS08595	1970402..1970698	+	297	WP_041753697.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
RBRH_RS08600	1970701..1971054	+	354	WP_013435791.1	putative addiction module antidote protein	Antitoxin
RBRH_RS08605	1971057..1971604	-	548	Protein_1719	hypothetical protein	-
RBRH_RS08610	1972099..1972950	-	852	WP_013435795.1	F-box protein	-
RBRH_RS08615	1973359..1974135	-	777	WP_157864410.1	GNAT family N-acetyltransferase	-
RBRH_RS08620	1974673..1975524	-	852	WP_041754369.1	dienelactone hydrolase family protein	-
RBRH_RS08625	1975542..1975829	-	288	WP_041754371.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Addiction module killer protein, predicted (1-97)

Antitoxin

• Uncharacterized protein HI1420 (5-92)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 10998.91 Da
• Isoelectric Point: 9.5399

>T24977 WP_041753697.1 NC_014722:1970402-1970698 [Mycetohabitans rhizoxinica HKI 454]
MFKILTTPQFDEWLDEVRAPVASAAINVRIERAKLDNLGYWRAVGEGVCEMKIDVGLGYRAYFVRRGKIIVVLLCGGDKS
TQKKNIKLAKKLAGELED

Nucleotide

• Length: 297 bp

>T24977 NC_014722:1970402-1970698 [Mycetohabitans rhizoxinica HKI 454]
ATGTTCAAAATTCTGACCACCCCTCAATTCGATGAGTGGCTCGACGAGGTTCGCGCCCCGGTCGCGAGCGCGGCGATTAA
CGTTCGCATCGAGCGCGCAAAGCTCGACAATCTTGGGTATTGGCGTGCTGTGGGCGAAGGCGTCTGCGAGATGAAGATCG
ACGTTGGTCTAGGCTACCGCGCCTACTTCGTGCGGCGGGGCAAAATCATTGTCGTGCTGCTGTGCGGTGGCGACAAATCA
ACGCAGAAAAAGAACATCAAACTGGCGAAAAAGCTCGCCGGCGAACTGGAGGATTAA

Antitoxin

Protein

• Length: 118 a.a.
• Molecular weight: 12569.37 Da
• Isoelectric Point: 9.5613

>AT24977 WP_013435791.1 NC_014722:1970701-1971054 [Mycetohabitans rhizoxinica HKI 454]
MKISELTEFDGSKYLKDEETVRHYLAQAFEDGDPRLIQAALGNVAKARGMTALARESGVKREALYRALSEGGNAEFATVM
KVVRALGLHLTIIASPVHAAEPAPAPTRARARTAAHA

Nucleotide

• Length: 354 bp

>AT24977 NC_014722:1970701-1971054 [Mycetohabitans rhizoxinica HKI 454]
ATGAAAATCAGCGAATTGACTGAATTCGACGGCTCGAAGTACCTAAAGGACGAGGAAACGGTTCGTCACTACCTGGCGCA
AGCGTTCGAGGATGGCGATCCGCGCCTGATTCAAGCCGCGCTCGGGAACGTCGCGAAGGCGCGCGGCATGACCGCGCTCG
CGCGCGAGTCCGGTGTGAAGCGAGAAGCGCTCTATCGGGCTCTGTCGGAAGGTGGGAACGCGGAGTTCGCAACGGTCATG
AAGGTAGTGCGCGCGTTGGGACTGCATCTGACCATCATTGCATCGCCCGTGCATGCGGCGGAACCCGCGCCGGCGCCAAC
TCGGGCGCGCGCGCGTACCGCCGCGCACGCGTAA

Structures

Antitoxin

• AlphaFold DB: E5ASI0