Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/DUF1778(antitoxin)
Location 2144059..2144859 Replicon chromosome
Accession NZ_CP099890
Organism Escherichia albertii strain 205_2_TBG_B

Toxin (Protein)


Gene name ataT Uniprot ID -
Locus tag NIZ17_RS10660 Protein ID WP_059228514.1
Coordinates 2144332..2144859 (+) Length 176 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID B1EHP0
Locus tag NIZ17_RS10655 Protein ID WP_001277106.1
Coordinates 2144059..2144325 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NIZ17_RS10630 (2139781) 2139781..2140635 - 855 WP_256880690.1 PTS system mannose/fructose/sorbose family transporter subunit IID -
NIZ17_RS10635 (2140628) 2140628..2141374 - 747 WP_000151888.1 PTS sugar transporter subunit IIC -
NIZ17_RS10640 (2141391) 2141391..2141876 - 486 WP_000029259.1 PTS sugar transporter subunit IIB -
NIZ17_RS10645 (2141883) 2141883..2142284 - 402 WP_001071334.1 PTS sugar transporter subunit IIA -
NIZ17_RS10650 (2142807) 2142807..2143910 + 1104 WP_256880691.1 branched chain amino acid ABC transporter substrate-binding protein LivJ -
NIZ17_RS10655 (2144059) 2144059..2144325 + 267 WP_001277106.1 type II toxin-antitoxin system antitoxin AtaR Antitoxin
NIZ17_RS10660 (2144332) 2144332..2144859 + 528 WP_059228514.1 type II toxin-antitoxin system toxin acetyltransferase AtaT Toxin
NIZ17_RS10665 (2144856) 2144856..2145239 - 384 WP_000778774.1 aspartate 1-decarboxylase autocleavage activator PanM -
NIZ17_RS10670 (2145663) 2145663..2146772 + 1110 WP_256880692.1 high-affinity branched-chain amino acid ABC transporter substrate-binding protein LivK -
NIZ17_RS10675 (2146820) 2146820..2147746 + 927 WP_001295097.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
NIZ17_RS10680 (2147743) 2147743..2149020 + 1278 WP_059216839.1 branched chain amino acid ABC transporter permease LivM -
NIZ17_RS10685 (2149017) 2149017..2149784 + 768 WP_000082094.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(90-150)

Antitoxin

Vibrio phage ICP1, Orf50

(8-86)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19623.53 Da        Isoelectric Point: 6.6303

>T249755 WP_059228514.1 NZ_CP099890:2144332-2144859 [Escherichia albertii]
MDDLTIEILTDDADYDLQRFDCGEEALNLFLTTHLVRQHRNKILRAYILCRNTPECQVLGYYTLSGSCFERAALPSKSKQ
KKIPYKNIPSVTLGRLAIDRSLQGQGWGATLVAHAMKVVWSASLAVGIHGLFVEALNEKAHTFYQSLGFIPLVGENENAL
FFPTKSIELLFTQSD

Download         Length: 528 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9942.37 Da        Isoelectric Point: 10.0863

>AT249755 WP_001277106.1 NZ_CP099890:2144059-2144325 [Escherichia albertii]
MSAVKKQRIDLRLTDDDKSMIEEAAAISNQSVSQFMLNSASQRAAEVIEQHRRMILNEESWTRVMDALSNPPSPGEKLKR
AAKRLQGM

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A7Z8E004

References