Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 1636765..1637357 Replicon chromosome
Accession NZ_CP099890
Organism Escherichia albertii strain 205_2_TBG_B

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag NIZ17_RS08190 Protein ID WP_256880610.1
Coordinates 1636765..1637139 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag NIZ17_RS08195 Protein ID WP_171002579.1
Coordinates 1637139..1637357 (-) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NIZ17_RS08175 (1634268) 1634268..1635170 + 903 WP_000331387.1 formate dehydrogenase O subunit beta -
NIZ17_RS08180 (1635167) 1635167..1635802 + 636 WP_059277370.1 formate dehydrogenase cytochrome b556 subunit -
NIZ17_RS08185 (1635799) 1635799..1636728 + 930 WP_000027704.1 formate dehydrogenase accessory protein FdhE -
NIZ17_RS08190 (1636765) 1636765..1637139 - 375 WP_256880610.1 type II toxin-antitoxin system VapC family toxin Toxin
NIZ17_RS08195 (1637139) 1637139..1637357 - 219 WP_171002579.1 CopG family transcriptional regulator Antitoxin
NIZ17_RS08200 (1637778) 1637778..1638056 - 279 WP_000102977.1 hypothetical protein -
NIZ17_RS08205 (1638108) 1638108..1638329 - 222 WP_256880611.1 cobalt ABC transporter ATP-binding protein -
NIZ17_RS08210 (1638414) 1638414..1638704 - 291 WP_000356397.1 NadS family protein -
NIZ17_RS08215 (1638705) 1638705..1639016 - 312 WP_000897302.1 hypothetical protein -
NIZ17_RS08220 (1639245) 1639245..1640153 + 909 WP_256880612.1 alpha/beta hydrolase -
NIZ17_RS08225 (1640217) 1640217..1641158 - 942 WP_001297068.1 fatty acid biosynthesis protein FabY -
NIZ17_RS08230 (1641203) 1641203..1641640 - 438 WP_000560977.1 D-aminoacyl-tRNA deacylase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-115)

Antitoxin

Ribbon-helix-helix protein, CopG

(4-40)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13928.15 Da        Isoelectric Point: 8.4539

>T249751 WP_256880610.1 NZ_CP099890:c1637139-1636765 [Escherichia albertii]
MAKRTALFDTNILIDLFSGRIEAKQALEAWPLQNAISLVTWMEVLVGAKKYNQEHRTQIAMSAFNVIGISQDIAERSVAL
RQEYRMKLPDAIILATAQIYGFELVTRNTRDFAGIAGVITPYQP

Download         Length: 375 bp

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 8495.64 Da        Isoelectric Point: 8.0083

>AT249751 WP_171002579.1 NZ_CP099890:c1637357-1637139 [Escherichia albertii]
MNTVFLHLSEEAIKRLNKLRGWRKVSRSAILREAVDQYLENQSKTTISSALGIWQGCEEDGVEYQRKLREEW

Download         Length: 219 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References