Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 502985..503603 Replicon chromosome
Accession NZ_CP099890
Organism Escherichia albertii strain 205_2_TBG_B

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag NIZ17_RS02475 Protein ID WP_001280991.1
Coordinates 503385..503603 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID B1EKM5
Locus tag NIZ17_RS02470 Protein ID WP_000344798.1
Coordinates 502985..503359 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NIZ17_RS02460 (498065) 498065..499258 + 1194 WP_010334435.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
NIZ17_RS02465 (499281) 499281..502430 + 3150 WP_001132500.1 efflux RND transporter permease AcrB -
NIZ17_RS02470 (502985) 502985..503359 + 375 WP_000344798.1 Hha toxicity modulator TomB Antitoxin
NIZ17_RS02475 (503385) 503385..503603 + 219 WP_001280991.1 HHA domain-containing protein Toxin
NIZ17_RS02480 (503780) 503780..504337 + 558 WP_000093561.1 maltose O-acetyltransferase -
NIZ17_RS02485 (504445) 504445..504915 + 471 WP_256880386.1 YlaC family protein -
NIZ17_RS02490 (505079) 505079..506629 + 1551 WP_001260378.1 EAL domain-containing protein -
NIZ17_RS02495 (506718) 506718..507886 + 1169 WP_102203946.1 IS3-like element IS911 family transposase -
NIZ17_RS02500 (507895) 507895..508161 - 267 Protein_481 DUF1428 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T249747 WP_001280991.1 NZ_CP099890:503385-503603 [Escherichia albertii]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14499.35 Da        Isoelectric Point: 4.8989

>AT249747 WP_000344798.1 NZ_CP099890:502985-503359 [Escherichia albertii]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKANPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A2T3RX90

References