Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataT-KacA/DUF1778(antitoxin)
Location 67683..68481 Replicon plasmid plas1
Accession NZ_CP099888
Organism Escherichia albertii strain 208_2_GWG_B

Toxin (Protein)


Gene name ataT Uniprot ID E2QDF3
Locus tag NIZ18_RS23300 Protein ID WP_000072677.1
Coordinates 67960..68481 (+) Length 174 a.a.

Antitoxin (Protein)


Gene name KacA Uniprot ID A0A0V9R6Q7
Locus tag NIZ18_RS23295 Protein ID WP_001351987.1
Coordinates 67683..67952 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NIZ18_RS23270 (NIZ18_23255) 63110..64450 - 1341 WP_000137333.1 DnaB-like helicase C-terminal domain-containing protein -
NIZ18_RS23275 (NIZ18_23260) 64494..65234 - 741 WP_187192596.1 hypothetical protein -
NIZ18_RS23280 (NIZ18_23265) 65517..66284 + 768 WP_000342417.1 hypothetical protein -
NIZ18_RS23285 (NIZ18_23270) 66337..66690 - 354 WP_160378290.1 hypothetical protein -
NIZ18_RS23290 (NIZ18_23275) 66696..67364 - 669 WP_000161228.1 division plane positioning ATPase MipZ -
NIZ18_RS23295 (NIZ18_23280) 67683..67952 + 270 WP_001351987.1 DUF1778 domain-containing protein Antitoxin
NIZ18_RS23300 (NIZ18_23285) 67960..68481 + 522 WP_000072677.1 GNAT family N-acetyltransferase Toxin
NIZ18_RS23305 (NIZ18_23290) 68650..68901 - 252 WP_000901559.1 hypothetical protein -
NIZ18_RS23310 (NIZ18_23295) 68903..69595 - 693 WP_012640731.1 hypothetical protein -
NIZ18_RS23315 (NIZ18_23300) 69609..69932 - 324 WP_000064175.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..109283 109283


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(72-150)

Antitoxin

Vibrio phage ICP1, Orf50

(8-86)


Sequences

Toxin        


Download         Length: 174 a.a.        Molecular weight: 19392.17 Da        Isoelectric Point: 8.6369

>T249744 WP_000072677.1 NZ_CP099888:67960-68481 [Escherichia albertii]
VSNTTIEIFSGEKDYDLNGFDCGEESLNAFLANHLKRQHEGKILRAYVLCTQEERPKVLGYYTLSGSCFEKESLPSRSKQ
KKVPYRNVPSVTLGRLALDKSLQGQGFGSMLVTHAMRVVYNASLAVGIHGLFVEALNDKAKAFYKSLGFIQLVGNNERSL
FYPTKSIEKLFEE

Download         Length: 522 bp

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10082.54 Da        Isoelectric Point: 7.0155

>AT249744 WP_001351987.1 NZ_CP099888:67683-67952 [Escherichia albertii]
MSALKKQRIDLRLTDDDKSIIEEAAAMSNQSITQFMVSSASERAVKVIEQHRRLVLNEESWNLVMDAISNPPAPNDKLKR
AADRLKSME

Download         Length: 270 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0V9R6P3

Antitoxin

Source ID Structure
AlphaFold DB A0A0V9R6Q7

References