Detailed information of TA system TA024974

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): pasABC/RelE-HTH
• Location: 1508660..1509140
• Replicon: chromosome
• Accession: NC_014722
• Organism: Burkholderia rhizoxinica HKI 454

Toxin (Protein)

• Gene name: pasB
• Uniprot ID: -
• Locus tag: RBRH_RS17175
• Protein ID: WP_013435405.1
• Coordinates: 1508871..1509140 (+)
• Length: 90 a.a.

Antitoxin (Protein)

• Gene name: pasA
• Uniprot ID: -
• Locus tag: RBRH_RS07010
• Protein ID: WP_041753558.1
• Coordinates: 1508660..1508887 (+)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
RBRH_RS18820	1504277..1504576	+	300	WP_013435397.1	hypothetical protein	-
RBRH_RS18825	1504573..1504866	+	294	WP_013435398.1	hypothetical protein	-
RBRH_RS07005	1505097..1506446	-	1350	WP_013435400.1	hypothetical protein	-
RBRH_RS17170	1507398..1508231	-	834	WP_083813446.1	class I SAM-dependent methyltransferase	-
RBRH_RS07010	1508660..1508887	+	228	WP_041753558.1	TraY domain-containing protein	Antitoxin
RBRH_RS17175	1508871..1509140	+	270	WP_013435405.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
RBRH_RS07015	1509587..1510517	+	931	Protein_1400	folate-binding protein YgfZ	-
RBRH_RS07020	1510628..1511242	-	615	WP_083813507.1	NADP-dependent oxidoreductase	-
RBRH_RS07025	1511265..1511783	-	519	WP_083813447.1	PaaI family thioesterase	-
RBRH_RS07030	1511773..1512057	-	285	WP_173362431.1	Dabb family protein	-
RBRH_RS07040	1512514..1514064	+	1551	WP_013435412.1	YdiU family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-88)

Antitoxin

• Protein of unknown function DUF6290 (1-70)

Sequences

Toxin

Protein

• Length: 90 a.a.
• Molecular weight: 10411.19 Da
• Isoelectric Point: 11.4164

>T24974 WP_013435405.1 NC_014722:1508871-1509140 [Mycetohabitans rhizoxinica HKI 454]
MAWKVELSSLARKNLKELNPQHARRILAFLHERVSVLDDPRSIGEALKGSRLRAFWKYRVGDCRIIANIEDSALRILVVR
IGNRREVYR

Nucleotide

• Length: 270 bp

>T24974 NC_014722:1508871-1509140 [Mycetohabitans rhizoxinica HKI 454]
ATGGCATGGAAGGTTGAGCTATCAAGTCTGGCACGCAAAAACCTTAAGGAACTTAACCCGCAACATGCTCGCCGTATTCT
GGCCTTCCTACATGAGCGTGTGTCCGTACTGGACGACCCTCGCAGCATTGGCGAAGCCCTCAAAGGTTCGCGCTTGAGGG
CTTTCTGGAAATACCGTGTCGGGGATTGCAGAATTATTGCTAATATCGAGGACAGCGCTTTGCGCATTCTCGTTGTTCGA
ATCGGAAACCGCCGCGAGGTGTACCGATGA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8433.58 Da
• Isoelectric Point: 4.4098

>AT24974 WP_041753558.1 NC_014722:1508660-1508887 [Mycetohabitans rhizoxinica HKI 454]
MALSIRLPGDVEARLKNLAELTGRTKSFYITEAICEHLDDLEDLYLAEHELEAIRAGKSETAPLEEVMKHYGMEG

Nucleotide

• Length: 228 bp

>AT24974 NC_014722:1508660-1508887 [Mycetohabitans rhizoxinica HKI 454]
ATGGCCCTTTCAATTCGACTGCCCGGCGATGTGGAAGCCCGGCTGAAGAACCTGGCCGAACTGACCGGGCGTACCAAGAG
CTTTTACATCACCGAGGCGATCTGCGAACATCTCGACGACCTCGAAGATTTGTACCTGGCTGAGCATGAGCTTGAAGCGA
TACGTGCGGGAAAATCCGAAACCGCACCGCTCGAAGAAGTGATGAAACACTATGGCATGGAAGGTTGA