Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3482241..3482859 Replicon chromosome
Accession NZ_CP099887
Organism Escherichia albertii strain 208_2_GWG_B

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag NIZ18_RS17060 Protein ID WP_001280991.1
Coordinates 3482641..3482859 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID -
Locus tag NIZ18_RS17055 Protein ID WP_256878553.1
Coordinates 3482241..3482615 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NIZ18_RS17045 (3477321) 3477321..3478514 + 1194 WP_010334435.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
NIZ18_RS17050 (3478537) 3478537..3481686 + 3150 WP_001132500.1 efflux RND transporter permease AcrB -
NIZ18_RS17055 (3482241) 3482241..3482615 + 375 WP_256878553.1 Hha toxicity modulator TomB Antitoxin
NIZ18_RS17060 (3482641) 3482641..3482859 + 219 WP_001280991.1 HHA domain-containing protein Toxin
NIZ18_RS17065 (3483036) 3483036..3483593 + 558 WP_025237467.1 maltose O-acetyltransferase -
NIZ18_RS17070 (3483700) 3483700..3484170 + 471 WP_000136188.1 YlaC family protein -
NIZ18_RS17075 (3484334) 3484334..3485883 + 1550 Protein_3342 EAL domain-containing protein -
NIZ18_RS17080 (3485921) 3485921..3486274 - 354 WP_000878151.1 DUF1428 family protein -
NIZ18_RS17090 (3486655) 3486655..3486966 + 312 WP_000409915.1 MGMT family protein -
NIZ18_RS17095 (3486996) 3486996..3487568 - 573 WP_256875765.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T249736 WP_001280991.1 NZ_CP099887:3482641-3482859 [Escherichia albertii]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14455.34 Da        Isoelectric Point: 5.1542

>AT249736 WP_256878553.1 NZ_CP099887:3482241-3482615 [Escherichia albertii]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQALQKWRKSGNRLFRCFVNATKANPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure

References