Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 930158..930809 Replicon chromosome
Accession NZ_CP099887
Organism Escherichia albertii strain 208_2_GWG_B

Toxin (Protein)


Gene name cptA Uniprot ID B1EG01
Locus tag NIZ18_RS04555 Protein ID WP_000244763.1
Coordinates 930405..930809 (+) Length 135 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag NIZ18_RS04550 Protein ID WP_000354046.1
Coordinates 930158..930424 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NIZ18_RS04525 (925869) 925869..927302 - 1434 WP_059235410.1 6-phospho-beta-glucosidase BglA -
NIZ18_RS04530 (927347) 927347..927658 + 312 WP_001182957.1 N(4)-acetylcytidine aminohydrolase -
NIZ18_RS04535 (927826) 927826..928485 + 660 WP_000250281.1 hemolysin III family protein -
NIZ18_RS04540 (928926) 928926..929906 - 981 WP_059235393.1 tRNA-modifying protein YgfZ -
NIZ18_RS04545 (929938) 929938..930168 + 231 WP_000181267.1 hypothetical protein -
NIZ18_RS04550 (930158) 930158..930424 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
NIZ18_RS04555 (930405) 930405..930809 + 405 WP_000244763.1 protein YgfX Toxin
NIZ18_RS04560 (930848) 930848..931369 - 522 WP_059235395.1 flavodoxin FldB -
NIZ18_RS04565 (931481) 931481..932377 + 897 WP_059228147.1 site-specific tyrosine recombinase XerD -
NIZ18_RS04570 (932402) 932402..933112 + 711 WP_000748106.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
NIZ18_RS04575 (933118) 933118..934851 + 1734 WP_000813238.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 15888.81 Da        Isoelectric Point: 11.1732

>T249728 WP_000244763.1 NZ_CP099887:930405-930809 [Escherichia albertii]
VVLWQSDLRVSWRAQWLSLLIHGLVAAAILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVRAPWMIKTGMMLRLLSDSGKRQHLWLAADSMDEAEWRDLRRILLQQEIQ

Download         Length: 405 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT249728 WP_000354046.1 NZ_CP099887:930158-930424 [Escherichia albertii]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2S6P9B3

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References