Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3164250..3164868 Replicon chromosome
Accession NZ_CP099886
Organism Escherichia albertii strain 222_1_EW_B

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag NIZ19_RS15280 Protein ID WP_001280991.1
Coordinates 3164250..3164468 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID B1EKM5
Locus tag NIZ19_RS15285 Protein ID WP_000344798.1
Coordinates 3164494..3164868 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NIZ19_RS15245 (3159539) 3159539..3160111 + 573 WP_256876988.1 YbaY family lipoprotein -
NIZ19_RS15250 (3160141) 3160141..3160452 - 312 WP_000409915.1 MGMT family protein -
NIZ19_RS15260 (3160833) 3160833..3161186 + 354 WP_000878151.1 DUF1428 family protein -
NIZ19_RS15265 (3161224) 3161224..3162774 - 1551 WP_099587736.1 EAL domain-containing protein -
NIZ19_RS15270 (3162938) 3162938..3163408 - 471 WP_000136187.1 YlaC family protein -
NIZ19_RS15275 (3163516) 3163516..3164073 - 558 WP_025237467.1 maltose O-acetyltransferase -
NIZ19_RS15280 (3164250) 3164250..3164468 - 219 WP_001280991.1 HHA domain-containing protein Toxin
NIZ19_RS15285 (3164494) 3164494..3164868 - 375 WP_000344798.1 Hha toxicity modulator TomB Antitoxin
NIZ19_RS15290 (3165423) 3165423..3168572 - 3150 WP_001132500.1 efflux RND transporter permease AcrB -
NIZ19_RS15295 (3168595) 3168595..3169788 - 1194 WP_010334435.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T249704 WP_001280991.1 NZ_CP099886:c3164468-3164250 [Escherichia albertii]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14499.35 Da        Isoelectric Point: 4.8989

>AT249704 WP_000344798.1 NZ_CP099886:c3164868-3164494 [Escherichia albertii]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKANPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A2T3RX90

References