Detailed information of TA system TA024970

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-Phd
• Location: 2500375..2500939
• Replicon: chromosome
• Accession: NC_014666
• Organism: Frankia sp. EuI1c

Toxin (Protein)

• Gene name: relE
• Uniprot ID: E3IV74
• Locus tag: FRAEUI1C_RS10185
• Protein ID: WP_013423213.1
• Coordinates: 2500375..2500647 (-)
• Length: 91 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: E3IV75
• Locus tag: FRAEUI1C_RS10190
• Protein ID: WP_013423214.1
• Coordinates: 2500658..2500939 (-)
• Length: 94 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FRAEUI1C_RS10160	2495842..2496867	-	1026	WP_013423208.1	LacI family transcriptional regulator	-
FRAEUI1C_RS10165	2496932..2497702	-	771	WP_013423209.1	DedA family protein	-
FRAEUI1C_RS10170	2497784..2498860	-	1077	WP_013423210.1	undecaprenyl-diphosphate phosphatase	-
FRAEUI1C_RS10175	2499044..2499442	+	399	WP_013423211.1	BlaI/MecI/CopY family transcriptional regulator	-
FRAEUI1C_RS10180	2499447..2500361	+	915	WP_013423212.1	M48 family metalloprotease	-
FRAEUI1C_RS10185	2500375..2500647	-	273	WP_013423213.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
FRAEUI1C_RS10190	2500658..2500939	-	282	WP_013423214.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
FRAEUI1C_RS10195	2501249..2502223	+	975	WP_013423215.1	aldo/keto reductase	-
FRAEUI1C_RS10200	2502310..2502927	+	618	WP_013423216.1	TetR family transcriptional regulator	-
FRAEUI1C_RS10205	2503077..2503562	+	486	WP_013423217.1	nuclear transport factor 2 family protein	-
FRAEUI1C_RS10210	2503642..2504862	+	1221	WP_013423218.1	cytochrome P450	-
FRAEUI1C_RS10215	2505084..2505530	+	447	WP_049807150.1	nuclear transport factor 2 family protein	-
FRAEUI1C_RS10220	2505652..2505915	-	264	WP_041259150.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-85)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (3-73)

Sequences

Toxin

Protein

• Length: 91 a.a.
• Molecular weight: 10266.82 Da
• Isoelectric Point: 11.0205

>T24970 WP_013423213.1 NC_014666:c2500647-2500375 [Frankia inefficax]
MSHQVVFTARAQRDLDQVPPRVVPAIVEFAFGDLADGPRRVGKPLDRELTGILSARRGPYRVLYRVDDDKKRVTILRVAH
RADAYRPWTA

Nucleotide

• Length: 273 bp

>T24970 NC_014666:c2500647-2500375 [Frankia inefficax]
ATGAGCCACCAGGTCGTCTTCACCGCGCGGGCTCAGCGCGACCTCGACCAGGTCCCGCCGCGCGTCGTTCCCGCGATTGT
CGAGTTCGCCTTCGGCGACCTTGCCGATGGGCCGAGGCGCGTAGGCAAGCCGCTCGACCGCGAACTCACCGGCATCCTCA
GCGCTCGTCGCGGCCCTTACCGCGTCCTCTACCGGGTCGATGACGACAAGAAACGCGTCACCATCCTGCGTGTGGCCCAC
CGAGCCGACGCCTACCGGCCGTGGACCGCCTGA

Antitoxin

Protein

• Length: 94 a.a.
• Molecular weight: 10158.31 Da
• Isoelectric Point: 4.2910

>AT24970 WP_013423214.1 NC_014666:c2500939-2500658 [Frankia inefficax]
VQTLPISKAKDRLNELVDAVALTREQVTITRNGSPAAVLVGVDEWESIQETLYWLSQPGIRESVAEADADADAGRVLGED
EMRARFGVPHGDR

Nucleotide

• Length: 282 bp

>AT24970 NC_014666:c2500939-2500658 [Frankia inefficax]
GTGCAGACGCTGCCTATCTCGAAGGCCAAGGACCGACTGAACGAACTAGTCGACGCCGTTGCCCTCACCCGCGAGCAGGT
CACCATCACCAGAAACGGTTCCCCGGCAGCCGTGCTCGTCGGCGTCGACGAGTGGGAGTCGATCCAGGAGACCCTGTACT
GGCTGTCCCAGCCAGGGATTCGCGAGTCCGTCGCCGAAGCGGACGCGGACGCCGACGCCGGACGGGTTCTCGGCGAGGAC
GAGATGCGCGCCCGCTTCGGCGTTCCCCACGGCGACCGGTGA

Structures

Toxin

• AlphaFold DB: E3IV74

Antitoxin

• AlphaFold DB: E3IV75