Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 2068975..2069591 Replicon chromosome
Accession NZ_CP099886
Organism Escherichia albertii strain 222_1_EW_B

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag NIZ19_RS10135 Protein ID WP_107192776.1
Coordinates 2069217..2069591 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag NIZ19_RS10130 Protein ID WP_103054107.1
Coordinates 2068975..2069217 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NIZ19_RS10090 (2064267) 2064267..2064704 + 438 WP_000560977.1 D-aminoacyl-tRNA deacylase -
NIZ19_RS10095 (2064749) 2064749..2065690 + 942 WP_001297068.1 fatty acid biosynthesis protein FabY -
NIZ19_RS10100 (2065754) 2065754..2066662 - 909 WP_059239594.1 alpha/beta hydrolase -
NIZ19_RS10105 (2066891) 2066891..2067202 + 312 WP_000897302.1 hypothetical protein -
NIZ19_RS10110 (2067203) 2067203..2067493 + 291 WP_000356397.1 NadS family protein -
NIZ19_RS10115 (2067578) 2067578..2067790 + 213 WP_000197774.1 hypothetical protein -
NIZ19_RS10120 (2067852) 2067852..2068130 + 279 WP_032278934.1 hypothetical protein -
NIZ19_RS10125 (2068529) 2068529..2068747 + 219 WP_001314326.1 CopG family transcriptional regulator -
NIZ19_RS10130 (2068975) 2068975..2069217 + 243 WP_103054107.1 CopG family transcriptional regulator Antitoxin
NIZ19_RS10135 (2069217) 2069217..2069591 + 375 WP_107192776.1 type II toxin-antitoxin system VapC family toxin Toxin
NIZ19_RS10140 (2069628) 2069628..2070557 - 930 WP_000027704.1 formate dehydrogenase accessory protein FdhE -
NIZ19_RS10145 (2070554) 2070554..2071189 - 636 WP_000829019.1 formate dehydrogenase cytochrome b556 subunit -
NIZ19_RS10150 (2071186) 2071186..2072088 - 903 WP_000331386.1 formate dehydrogenase O subunit beta -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-115)

Antitoxin

Ribbon-helix-helix protein, CopG

(15-48)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13944.15 Da        Isoelectric Point: 8.4539

>T249696 WP_107192776.1 NZ_CP099886:2069217-2069591 [Escherichia albertii]
MAKRTALFDTNILIDLFSGRIESKQALEAWPLQNAISLVTWMEVLVGAKKYNQEHRTQIAMSAFNVIGISQDIAERSVAL
RQEYRMKLPDAIILATAQIYGFELVTRNTRDFAGIAGVITPYQP

Download         Length: 375 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9272.61 Da        Isoelectric Point: 4.4819

>AT249696 WP_103054107.1 NZ_CP099886:2068975-2069217 [Escherichia albertii]
MSAMAGMDMGRILLDLSDEVIKRLDDLKVQRNLPRAELLREAVAQYLENQSKTTIFSALGIWQGCEEDGVEYQRKLREEW

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References