Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1798656..1799307 Replicon chromosome
Accession NZ_CP099886
Organism Escherichia albertii strain 222_1_EW_B

Toxin (Protein)


Gene name cptA Uniprot ID -
Locus tag NIZ19_RS08840 Protein ID WP_161537425.1
Coordinates 1798903..1799307 (+) Length 135 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag NIZ19_RS08835 Protein ID WP_000354046.1
Coordinates 1798656..1798922 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NIZ19_RS08810 (1794368) 1794368..1795801 - 1434 WP_256877592.1 6-phospho-beta-glucosidase BglA -
NIZ19_RS08815 (1795846) 1795846..1796157 + 312 WP_001182957.1 N(4)-acetylcytidine aminohydrolase -
NIZ19_RS08820 (1796325) 1796325..1796984 + 660 WP_000250281.1 hemolysin III family protein -
NIZ19_RS08825 (1797424) 1797424..1798404 - 981 WP_256877593.1 tRNA-modifying protein YgfZ -
NIZ19_RS08830 (1798436) 1798436..1798666 + 231 WP_000181267.1 hypothetical protein -
NIZ19_RS08835 (1798656) 1798656..1798922 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
NIZ19_RS08840 (1798903) 1798903..1799307 + 405 WP_161537425.1 protein YgfX Toxin
NIZ19_RS08845 (1799346) 1799346..1799867 - 522 WP_025238422.1 flavodoxin FldB -
NIZ19_RS08850 (1799979) 1799979..1800875 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
NIZ19_RS08855 (1800900) 1800900..1801610 + 711 WP_000748106.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
NIZ19_RS08860 (1801616) 1801616..1803349 + 1734 WP_000813238.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 15819.70 Da        Isoelectric Point: 10.7510

>T249694 WP_161537425.1 NZ_CP099886:1798903-1799307 [Escherichia albertii]
VVLWQSDLRVSWRAQWLSLLIHGLVAAAILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVSAPWMIKTGMMLRLLSDSGKRQHLWLAADSMDEAEWRDLRRILLQQEIQ

Download         Length: 405 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT249694 WP_000354046.1 NZ_CP099886:1798656-1798922 [Escherichia albertii]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References