Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/DUF1778(antitoxin)
Location 1191174..1191974 Replicon chromosome
Accession NZ_CP099886
Organism Escherichia albertii strain 222_1_EW_B

Toxin (Protein)


Gene name ataT Uniprot ID -
Locus tag NIZ19_RS05840 Protein ID WP_256877506.1
Coordinates 1191447..1191974 (+) Length 176 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID A0A8H9C3F4
Locus tag NIZ19_RS05835 Protein ID WP_001277105.1
Coordinates 1191174..1191440 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NIZ19_RS05810 (1186895) 1186895..1187749 - 855 WP_000370583.1 PTS system mannose/fructose/sorbose family transporter subunit IID -
NIZ19_RS05815 (1187742) 1187742..1188488 - 747 WP_256877504.1 PTS sugar transporter subunit IIC -
NIZ19_RS05820 (1188505) 1188505..1188990 - 486 WP_000029259.1 PTS sugar transporter subunit IIB -
NIZ19_RS05825 (1188997) 1188997..1189398 - 402 WP_001071334.1 PTS sugar transporter subunit IIA -
NIZ19_RS05830 (1189921) 1189921..1191024 + 1104 WP_256877505.1 branched chain amino acid ABC transporter substrate-binding protein LivJ -
NIZ19_RS05835 (1191174) 1191174..1191440 + 267 WP_001277105.1 type II toxin-antitoxin system antitoxin AtaR Antitoxin
NIZ19_RS05840 (1191447) 1191447..1191974 + 528 WP_256877506.1 type II toxin-antitoxin system toxin acetyltransferase AtaT Toxin
NIZ19_RS05845 (1191971) 1191971..1192354 - 384 WP_000778774.1 aspartate 1-decarboxylase autocleavage activator PanM -
NIZ19_RS05850 (1192778) 1192778..1193887 + 1110 WP_000827694.1 high-affinity branched-chain amino acid ABC transporter substrate-binding protein LivK -
NIZ19_RS05855 (1193935) 1193935..1194861 + 927 WP_001295097.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
NIZ19_RS05860 (1194858) 1194858..1196135 + 1278 WP_256877507.1 branched chain amino acid ABC transporter permease LivM -
NIZ19_RS05865 (1196132) 1196132..1196899 + 768 WP_044709901.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(90-150)

Antitoxin

Vibrio phage ICP1, Orf50

(2-86)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19535.40 Da        Isoelectric Point: 6.9580

>T249692 WP_256877506.1 NZ_CP099886:1191447-1191974 [Escherichia albertii]
MDDLTIEILTDDADYDLQRFDCGEEALNLFLTTHLVRQHRNKILRAYILCSNTPERQVLGYYTLSGSCFERAALPSKSKQ
KKIPYKNIPSVTLGRLAIDRSLQGQGWGATLVAHAMKVVWSASLAVGIHGLFVGALNEKAHTFYQSLGFIPLVGENENAL
FFPTKSIELLFTQSD

Download         Length: 528 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9935.40 Da        Isoelectric Point: 9.2494

>AT249692 WP_001277105.1 NZ_CP099886:1191174-1191440 [Escherichia albertii]
MSAVKKQRIDLRLTDDDKSMIEEAAAISNQSVSQFMLNCASQRAAEVIEQNRRMILNEESWTRVMDALSNPPSPGEKLKR
AAKRLQGM

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References