Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 2353..2996 Replicon plasmid plas2
Accession NZ_CP099885
Organism Escherichia albertii strain 231_1_NP_B

Toxin (Protein)


Gene name vagD Uniprot ID -
Locus tag NIZ20_RS24120 Protein ID WP_256876211.1
Coordinates 2353..2769 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID -
Locus tag NIZ20_RS24125 Protein ID WP_256876210.1
Coordinates 2766..2996 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NIZ20_RS24110 (668) 668..829 + 162 WP_256880875.1 hypothetical protein -
NIZ20_RS24115 (1234) 1234..2213 - 980 Protein_2 hypothetical protein -
NIZ20_RS24120 (2353) 2353..2769 - 417 WP_256876211.1 type II toxin-antitoxin system VapC family toxin Toxin
NIZ20_RS24125 (2766) 2766..2996 - 231 WP_256876210.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
NIZ20_RS24130 (3565) 3565..3978 + 414 WP_000465043.1 hypothetical protein -
NIZ20_RS24135 (3980) 3980..4762 + 783 WP_021533580.1 site-specific integrase -
NIZ20_RS24140 (4935) 4935..5288 + 354 WP_000864812.1 colicin M immunity protein -
NIZ20_RS24145 (5338) 5338..6153 - 816 WP_000449473.1 lipid II-degrading bacteriocin colicin M -
NIZ20_RS24150 (6396) 6396..6923 + 528 WP_000203268.1 colicin B immunity protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - espL2 1..89097 89097


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-49)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15080.41 Da        Isoelectric Point: 6.7125

>T249687 WP_256876211.1 NZ_CP099885:c2769-2353 [Escherichia albertii]
VNKIYMLDTNICSFIMREQPEAVLKRLEQAVLRGHRIVVSAITYSEMRFGATGPKASPRHVQLVDAFCERLDAVLPWDRA
AVDATTEIKVALRLAGTPIGPNDTAISGHAIAAGAILVTNNTREFERVPGLILEDWAG

Download         Length: 417 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8678.80 Da        Isoelectric Point: 4.6017

>AT249687 WP_256876210.1 NZ_CP099885:c2996-2766 [Escherichia albertii]
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGGSIILRPVRPTWGSFAQLEKADPDFMAEREDVISDEGRFNL

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References