Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-Phd
Location 57882..58483 Replicon plasmid plas1
Accession NZ_CP099884
Organism Escherichia albertii strain 231_1_NP_B

Toxin (Protein)


Gene name doc Uniprot ID U9YA20
Locus tag NIZ20_RS23825 Protein ID WP_001216045.1
Coordinates 57882..58262 (-) Length 127 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID U9YQH9
Locus tag NIZ20_RS23830 Protein ID WP_001190712.1
Coordinates 58262..58483 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NIZ20_RS23795 (NIZ20_23770) 53008..53238 - 231 Protein_54 ash family protein -
NIZ20_RS23800 (NIZ20_23775) 53322..54806 - 1485 WP_000124159.1 hypothetical protein -
NIZ20_RS23805 (NIZ20_23780) 54806..55999 - 1194 WP_000219618.1 hypothetical protein -
NIZ20_RS23810 (NIZ20_23785) 56086..56538 - 453 WP_001326849.1 late promoter-activating protein -
NIZ20_RS23815 (NIZ20_23790) 56627..57670 - 1044 WP_256876191.1 DUF968 domain-containing protein -
NIZ20_RS23820 (NIZ20_23795) 57698..57877 - 180 WP_000113019.1 hypothetical protein -
NIZ20_RS23825 (NIZ20_23800) 57882..58262 - 381 WP_001216045.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
NIZ20_RS23830 (NIZ20_23805) 58262..58483 - 222 WP_001190712.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
NIZ20_RS23835 (NIZ20_23810) 58666..60222 + 1557 WP_073511017.1 type I restriction-modification system subunit M -
NIZ20_RS23840 (NIZ20_23815) 60219..61445 + 1227 WP_256876192.1 restriction endonuclease subunit S -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..110294 110294


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(3-120)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-51)


Sequences

Toxin        


Download         Length: 127 a.a.        Molecular weight: 13588.29 Da        Isoelectric Point: 5.1514

>T249686 WP_001216045.1 NZ_CP099884:c58262-57882 [Escherichia albertii]
MRHISPEELIALHDANISRYGGLPGMSDPGRAEAIIGRVQARVAYEEITDLFEVSATYLVATARGHIFNDANKRTALNSA
LLFLRRNGVQVFDSPELADLTVGAATGEISVSSVADTLRRLYGSAE

Download         Length: 381 bp

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8133.10 Da        Isoelectric Point: 4.7708

>AT249686 WP_001190712.1 NZ_CP099884:c58483-58262 [Escherichia albertii]
MQSINFRTARGNLSEVLNNVEAGEEVEITRRGREPAVIVSKATFEAYKKAALDAEFASLFDTLDSTNKELVNR

Download         Length: 222 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CLP7

Antitoxin

Source ID Structure
AlphaFold DB A0A829CJB6

References