Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/PRK09812-MazE
Location 2411508..2412098 Replicon chromosome
Accession NZ_CP099883
Organism Escherichia albertii strain 231_1_NP_B

Toxin (Protein)


Gene name pemK Uniprot ID -
Locus tag NIZ20_RS11895 Protein ID WP_059225520.1
Coordinates 2411508..2411840 (-) Length 111 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID -
Locus tag NIZ20_RS11900 Protein ID WP_059225519.1
Coordinates 2411841..2412098 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NIZ20_RS11875 (2407212) 2407212..2408474 + 1263 WP_059225524.1 integrase arm-type DNA-binding domain-containing protein -
NIZ20_RS11880 (2409433) 2409433..2409720 + 288 WP_059225522.1 hypothetical protein -
NIZ20_RS11885 (2409816) 2409816..2410700 - 885 WP_059225521.1 integrase domain-containing protein -
NIZ20_RS11890 (2411018) 2411018..2411395 - 378 WP_161537949.1 hypothetical protein -
NIZ20_RS11895 (2411508) 2411508..2411840 - 333 WP_059225520.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
NIZ20_RS11900 (2411841) 2411841..2412098 - 258 WP_059225519.1 hypothetical protein Antitoxin
NIZ20_RS11905 (2412446) 2412446..2412651 - 206 Protein_2322 helix-turn-helix domain-containing protein -
NIZ20_RS11910 (2412648) 2412648..2413118 - 471 WP_059225518.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-108)

Antitoxin

Antitoxin PemI-like

(4-85)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 11777.59 Da        Isoelectric Point: 8.0291

>T249681 WP_059225520.1 NZ_CP099883:c2411840-2411508 [Escherichia albertii]
MDRGEIWLVSLDPIAGHEQSGKRPVLIVSPASFNEVTRLPVIVPVTSGGQFARSAGFAVSLEGAGTKTTGIIRCDQPRTI
DMGARNGKRLERIPDGIINEVLARLETILA

Download         Length: 333 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9314.80 Da        Isoelectric Point: 4.4488

>AT249681 WP_059225519.1 NZ_CP099883:c2412098-2411841 [Escherichia albertii]
MYTTRLKKVGGSVMLAVPPAVLKTLALLPDSEVGVTIDNGCLIIEPQKRPRYSLAELLAQCDPHEEISDEEREWIDAPAA
GKEIL

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References