Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 798699..799317 Replicon chromosome
Accession NZ_CP099883
Organism Escherichia albertii strain 231_1_NP_B

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag NIZ20_RS03785 Protein ID WP_001280991.1
Coordinates 798699..798917 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID B1EKM5
Locus tag NIZ20_RS03790 Protein ID WP_000344798.1
Coordinates 798943..799317 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NIZ20_RS03750 (793988) 793988..794560 + 573 WP_000779847.1 YbaY family lipoprotein -
NIZ20_RS03755 (794590) 794590..794901 - 312 WP_000409915.1 MGMT family protein -
NIZ20_RS03765 (795282) 795282..795635 + 354 WP_000878151.1 DUF1428 family protein -
NIZ20_RS03770 (795673) 795673..797223 - 1551 WP_256876043.1 EAL domain-containing protein -
NIZ20_RS03775 (797387) 797387..797857 - 471 WP_059224581.1 YlaC family protein -
NIZ20_RS03780 (797965) 797965..798522 - 558 WP_000093561.1 maltose O-acetyltransferase -
NIZ20_RS03785 (798699) 798699..798917 - 219 WP_001280991.1 HHA domain-containing protein Toxin
NIZ20_RS03790 (798943) 798943..799317 - 375 WP_000344798.1 Hha toxicity modulator TomB Antitoxin
NIZ20_RS03795 (799872) 799872..803021 - 3150 WP_001132500.1 efflux RND transporter permease AcrB -
NIZ20_RS03800 (803044) 803044..804237 - 1194 WP_010334435.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T249671 WP_001280991.1 NZ_CP099883:c798917-798699 [Escherichia albertii]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14499.35 Da        Isoelectric Point: 4.8989

>AT249671 WP_000344798.1 NZ_CP099883:c799317-798943 [Escherichia albertii]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKANPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A2T3RX90

References