Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 28187..28830 Replicon plasmid plas2
Accession NZ_CP099882
Organism Escherichia albertii strain 233_2_GWG_B

Toxin (Protein)


Gene name vagD Uniprot ID -
Locus tag NIZ21_RS24240 Protein ID WP_256876211.1
Coordinates 28187..28603 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID -
Locus tag NIZ21_RS24245 Protein ID WP_256876210.1
Coordinates 28600..28830 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NIZ21_RS24215 (23238) 23238..23579 - 342 Protein_19 protein RepA -
NIZ21_RS24220 (24116) 24116..24712 - 597 WP_256876215.1 hypothetical protein -
NIZ21_RS24225 (24700) 24700..24969 - 270 WP_256876214.1 hypothetical protein -
NIZ21_RS24230 (25288) 25288..26859 + 1572 WP_256876213.1 ATP-binding protein -
NIZ21_RS24235 (27067) 27067..28047 - 981 WP_256876212.1 hypothetical protein -
NIZ21_RS24240 (28187) 28187..28603 - 417 WP_256876211.1 type II toxin-antitoxin system VapC family toxin Toxin
NIZ21_RS24245 (28600) 28600..28830 - 231 WP_256876210.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
NIZ21_RS24250 (29399) 29399..29812 + 414 WP_000465043.1 hypothetical protein -
NIZ21_RS24255 (29814) 29814..30596 + 783 WP_021533580.1 site-specific integrase -
NIZ21_RS24260 (30769) 30769..31122 + 354 WP_000864812.1 colicin M immunity protein -
NIZ21_RS24265 (31172) 31172..31987 - 816 WP_000449473.1 lipid II-degrading bacteriocin colicin M -
NIZ21_RS24270 (32230) 32230..32757 + 528 WP_000203268.1 colicin B immunity protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - espL2 1..89091 89091


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-49)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15080.41 Da        Isoelectric Point: 6.7125

>T249661 WP_256876211.1 NZ_CP099882:c28603-28187 [Escherichia albertii]
VNKIYMLDTNICSFIMREQPEAVLKRLEQAVLRGHRIVVSAITYSEMRFGATGPKASPRHVQLVDAFCERLDAVLPWDRA
AVDATTEIKVALRLAGTPIGPNDTAISGHAIAAGAILVTNNTREFERVPGLILEDWAG

Download         Length: 417 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8678.80 Da        Isoelectric Point: 4.6017

>AT249661 WP_256876210.1 NZ_CP099882:c28830-28600 [Escherichia albertii]
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGGSIILRPVRPTWGSFAQLEKADPDFMAEREDVISDEGRFNL

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References