Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-Phd
Location 55877..56478 Replicon plasmid plas1
Accession NZ_CP099881
Organism Escherichia albertii strain 233_2_GWG_B

Toxin (Protein)


Gene name doc Uniprot ID U9YA20
Locus tag NIZ21_RS23915 Protein ID WP_001216045.1
Coordinates 56098..56478 (+) Length 127 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID U9YQH9
Locus tag NIZ21_RS23910 Protein ID WP_001190712.1
Coordinates 55877..56098 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NIZ21_RS23900 (NIZ21_23875) 52915..54141 - 1227 WP_256876192.1 restriction endonuclease subunit S -
NIZ21_RS23905 (NIZ21_23880) 54138..55694 - 1557 WP_073511017.1 type I restriction-modification system subunit M -
NIZ21_RS23910 (NIZ21_23885) 55877..56098 + 222 WP_001190712.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
NIZ21_RS23915 (NIZ21_23890) 56098..56478 + 381 WP_001216045.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
NIZ21_RS23920 (NIZ21_23895) 56483..56662 + 180 WP_000113019.1 hypothetical protein -
NIZ21_RS23925 (NIZ21_23900) 56690..57733 + 1044 WP_256876191.1 DUF968 domain-containing protein -
NIZ21_RS23930 (NIZ21_23905) 57822..58274 + 453 WP_001326849.1 late promoter-activating protein -
NIZ21_RS23935 (NIZ21_23910) 58361..59554 + 1194 WP_000219618.1 hypothetical protein -
NIZ21_RS23940 (NIZ21_23915) 59554..61038 + 1485 WP_000124159.1 hypothetical protein -
NIZ21_RS23945 (NIZ21_23920) 61122..61352 + 231 Protein_61 ash family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..97175 97175


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(3-120)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-51)


Sequences

Toxin        


Download         Length: 127 a.a.        Molecular weight: 13588.29 Da        Isoelectric Point: 5.1514

>T249660 WP_001216045.1 NZ_CP099881:56098-56478 [Escherichia albertii]
MRHISPEELIALHDANISRYGGLPGMSDPGRAEAIIGRVQARVAYEEITDLFEVSATYLVATARGHIFNDANKRTALNSA
LLFLRRNGVQVFDSPELADLTVGAATGEISVSSVADTLRRLYGSAE

Download         Length: 381 bp

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8133.10 Da        Isoelectric Point: 4.7708

>AT249660 WP_001190712.1 NZ_CP099881:55877-56098 [Escherichia albertii]
MQSINFRTARGNLSEVLNNVEAGEEVEITRRGREPAVIVSKATFEAYKKAALDAEFASLFDTLDSTNKELVNR

Download         Length: 222 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CLP7

Antitoxin

Source ID Structure
AlphaFold DB A0A829CJB6

References