Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3542780..3543398 Replicon chromosome
Accession NZ_CP099880
Organism Escherichia albertii strain 233_2_GWG_B

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag NIZ21_RS17385 Protein ID WP_001280991.1
Coordinates 3543180..3543398 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID B1EKM5
Locus tag NIZ21_RS17380 Protein ID WP_000344798.1
Coordinates 3542780..3543154 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NIZ21_RS17370 (3537860) 3537860..3539053 + 1194 WP_010334435.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
NIZ21_RS17375 (3539076) 3539076..3542225 + 3150 WP_001132500.1 efflux RND transporter permease AcrB -
NIZ21_RS17380 (3542780) 3542780..3543154 + 375 WP_000344798.1 Hha toxicity modulator TomB Antitoxin
NIZ21_RS17385 (3543180) 3543180..3543398 + 219 WP_001280991.1 HHA domain-containing protein Toxin
NIZ21_RS17390 (3543575) 3543575..3544132 + 558 WP_000093561.1 maltose O-acetyltransferase -
NIZ21_RS17395 (3544240) 3544240..3544710 + 471 WP_059224581.1 YlaC family protein -
NIZ21_RS17400 (3544874) 3544874..3546424 + 1551 WP_256876043.1 EAL domain-containing protein -
NIZ21_RS17405 (3546462) 3546462..3546815 - 354 WP_000878151.1 DUF1428 family protein -
NIZ21_RS17415 (3547196) 3547196..3547507 + 312 WP_000409915.1 MGMT family protein -
NIZ21_RS17420 (3547537) 3547537..3548109 - 573 WP_000779847.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T249651 WP_001280991.1 NZ_CP099880:3543180-3543398 [Escherichia albertii]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14499.35 Da        Isoelectric Point: 4.8989

>AT249651 WP_000344798.1 NZ_CP099880:3542780-3543154 [Escherichia albertii]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKANPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A2T3RX90

References