Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/PRK09812-MazE
Location 1962492..1963082 Replicon chromosome
Accession NZ_CP099880
Organism Escherichia albertii strain 233_2_GWG_B

Toxin (Protein)


Gene name pemK Uniprot ID -
Locus tag NIZ21_RS09495 Protein ID WP_059225520.1
Coordinates 1962750..1963082 (+) Length 111 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID -
Locus tag NIZ21_RS09490 Protein ID WP_059225519.1
Coordinates 1962492..1962749 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NIZ21_RS09480 (1961472) 1961472..1961942 + 471 WP_059225518.1 hypothetical protein -
NIZ21_RS09485 (1961939) 1961939..1962144 + 206 Protein_1853 helix-turn-helix domain-containing protein -
NIZ21_RS09490 (1962492) 1962492..1962749 + 258 WP_059225519.1 hypothetical protein Antitoxin
NIZ21_RS09495 (1962750) 1962750..1963082 + 333 WP_059225520.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
NIZ21_RS09500 (1963195) 1963195..1963572 + 378 WP_161537949.1 hypothetical protein -
NIZ21_RS09505 (1963890) 1963890..1964774 + 885 WP_059225521.1 integrase domain-containing protein -
NIZ21_RS09510 (1964870) 1964870..1965157 - 288 WP_059225522.1 hypothetical protein -
NIZ21_RS09515 (1966116) 1966116..1967378 - 1263 WP_059225524.1 integrase arm-type DNA-binding domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-108)

Antitoxin

Antitoxin PemI-like

(4-85)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 11777.59 Da        Isoelectric Point: 8.0291

>T249641 WP_059225520.1 NZ_CP099880:1962750-1963082 [Escherichia albertii]
MDRGEIWLVSLDPIAGHEQSGKRPVLIVSPASFNEVTRLPVIVPVTSGGQFARSAGFAVSLEGAGTKTTGIIRCDQPRTI
DMGARNGKRLERIPDGIINEVLARLETILA

Download         Length: 333 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9314.80 Da        Isoelectric Point: 4.4488

>AT249641 WP_059225519.1 NZ_CP099880:1962492-1962749 [Escherichia albertii]
MYTTRLKKVGGSVMLAVPPAVLKTLALLPDSEVGVTIDNGCLIIEPQKRPRYSLAELLAQCDPHEEISDEEREWIDAPAA
GKEIL

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References