Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/DUF1778(antitoxin)
Location 298167..298967 Replicon chromosome
Accession NZ_CP099880
Organism Escherichia albertii strain 233_2_GWG_B

Toxin (Protein)


Gene name ataT Uniprot ID -
Locus tag NIZ21_RS01385 Protein ID WP_059225129.1
Coordinates 298440..298967 (+) Length 176 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID B1EHP0
Locus tag NIZ21_RS01380 Protein ID WP_001277106.1
Coordinates 298167..298433 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NIZ21_RS01360 (293824) 293824..294492 + 669 WP_000617720.1 cell division ATP-binding protein FtsE -
NIZ21_RS01365 (294485) 294485..295543 + 1059 WP_001042000.1 permease-like cell division protein FtsX -
NIZ21_RS01370 (295788) 295788..296642 + 855 WP_000130217.1 RNA polymerase sigma factor RpoH -
NIZ21_RS01375 (296914) 296914..298017 + 1104 WP_072248450.1 branched chain amino acid ABC transporter substrate-binding protein LivJ -
NIZ21_RS01380 (298167) 298167..298433 + 267 WP_001277106.1 type II toxin-antitoxin system antitoxin AtaR Antitoxin
NIZ21_RS01385 (298440) 298440..298967 + 528 WP_059225129.1 type II toxin-antitoxin system toxin acetyltransferase AtaT Toxin
NIZ21_RS01390 (298964) 298964..299347 - 384 WP_000778776.1 aspartate 1-decarboxylase autocleavage activator PanM -
NIZ21_RS01395 (299771) 299771..300880 + 1110 Protein_275 high-affinity branched-chain amino acid ABC transporter substrate-binding protein LivK -
NIZ21_RS01400 (300928) 300928..301854 + 927 WP_001295097.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
NIZ21_RS01405 (301851) 301851..303128 + 1278 WP_256877739.1 branched chain amino acid ABC transporter permease LivM -
NIZ21_RS01410 (303125) 303125..303892 + 768 WP_044709901.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(88-150)

Antitoxin

Vibrio phage ICP1, Orf50

(8-86)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19690.60 Da        Isoelectric Point: 6.9585

>T249638 WP_059225129.1 NZ_CP099880:298440-298967 [Escherichia albertii]
MDDLTIEILTDDADYDLQRFDCGEEALNLFLTTHLVRQHRNKILRAYILCRNTPERQVLGYYTLSGSCFERAALPSKSKQ
KKIPYKNIPSVTLGRLAIDRSLQGQGWGATLIAHAMKVVWSASLAVGIHGLFVEALNEKAHTFYQSLGFIPLVGENENAL
FFPTKSIELLFTQSD

Download         Length: 528 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9942.37 Da        Isoelectric Point: 10.0863

>AT249638 WP_001277106.1 NZ_CP099880:298167-298433 [Escherichia albertii]
MSAVKKQRIDLRLTDDDKSMIEEAAAISNQSVSQFMLNSASQRAAEVIEQHRRMILNEESWTRVMDALSNPPSPGEKLKR
AAKRLQGM

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A7Z8E004

References