Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3481577..3482195 Replicon chromosome
Accession NZ_CP099877
Organism Escherichia albertii strain 247_2_EW_B

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag NIZ22_RS17065 Protein ID WP_001280991.1
Coordinates 3481977..3482195 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID -
Locus tag NIZ22_RS17060 Protein ID WP_256878553.1
Coordinates 3481577..3481951 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NIZ22_RS17050 (3476657) 3476657..3477850 + 1194 WP_010334435.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
NIZ22_RS17055 (3477873) 3477873..3481022 + 3150 WP_001132500.1 efflux RND transporter permease AcrB -
NIZ22_RS17060 (3481577) 3481577..3481951 + 375 WP_256878553.1 Hha toxicity modulator TomB Antitoxin
NIZ22_RS17065 (3481977) 3481977..3482195 + 219 WP_001280991.1 HHA domain-containing protein Toxin
NIZ22_RS17070 (3482372) 3482372..3482929 + 558 WP_025237467.1 maltose O-acetyltransferase -
NIZ22_RS17075 (3483036) 3483036..3483506 + 471 WP_000136188.1 YlaC family protein -
NIZ22_RS17080 (3483670) 3483670..3485219 + 1550 Protein_3333 EAL domain-containing protein -
NIZ22_RS17085 (3485257) 3485257..3485610 - 354 WP_000878151.1 DUF1428 family protein -
NIZ22_RS17095 (3485991) 3485991..3486302 + 312 WP_000409915.1 MGMT family protein -
NIZ22_RS17100 (3486332) 3486332..3486904 - 573 WP_256875765.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T249626 WP_001280991.1 NZ_CP099877:3481977-3482195 [Escherichia albertii]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14455.34 Da        Isoelectric Point: 5.1542

>AT249626 WP_256878553.1 NZ_CP099877:3481577-3481951 [Escherichia albertii]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQALQKWRKSGNRLFRCFVNATKANPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure

References