Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 142033..142645 Replicon chromosome
Accession NZ_CP099877
Organism Escherichia albertii strain 247_2_EW_B

Toxin (Protein)


Gene name hicA Uniprot ID U9YXE2
Locus tag NIZ22_RS00620 Protein ID WP_000833473.1
Coordinates 142033..142218 (+) Length 62 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag NIZ22_RS00625 Protein ID WP_059235556.1
Coordinates 142235..142645 (+) Length 137 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NIZ22_RS00605 (137497) 137497..138792 + 1296 WP_059235552.1 Fic family protein -
NIZ22_RS00610 (138900) 138900..140438 + 1539 WP_002460288.1 aldehyde dehydrogenase AldB -
NIZ22_RS00615 (140479) 140479..141558 - 1080 WP_025238097.1 type I restriction enzyme HsdR N-terminal domain-containing protein -
NIZ22_RS00620 (142033) 142033..142218 + 186 WP_000833473.1 type II toxin-antitoxin system HicA family toxin Toxin
NIZ22_RS00625 (142235) 142235..142645 + 411 WP_059235556.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
NIZ22_RS00630 (142717) 142717..144681 - 1965 WP_256875795.1 glycoside hydrolase family 127 protein -
NIZ22_RS00635 (144692) 144692..146092 - 1401 WP_025238099.1 MFS transporter -
NIZ22_RS00640 (146318) 146318..147133 + 816 WP_059242247.1 AraC family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-129)


Sequences

Toxin        


Download         Length: 62 a.a.        Molecular weight: 6800.89 Da        Isoelectric Point: 11.7053

>T249612 WP_000833473.1 NZ_CP099877:142033-142218 [Escherichia albertii]
VKSADVIAILKQHGWEHIRTRGSHHQFRHPVHPGLVTVPHPKKDIKPGTLAQIGRQAGLTF

Download         Length: 186 bp

Antitoxin


Download         Length: 137 a.a.        Molecular weight: 15193.10 Da        Isoelectric Point: 4.5486

>AT249612 WP_059235556.1 NZ_CP099877:142235-142645 [Escherichia albertii]
MFYPAYIHSDPDGSASGFFPDVPGCYFAGDTLDNAFQDARSALVAHFETLCEMNEELPLPGSVETHLVQRAQDFIGGQWL
LVDINMNQVEGRAERINITMPKRLLNKIDTYVRNNPDYANRSAFLAEAARRVLPGV

Download         Length: 411 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9YXE2

Antitoxin

Source ID Structure

References