Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 201492..202057 Replicon chromosome
Accession NC_014643
Organism Rothia dentocariosa ATCC 17931

Toxin (Protein)


Gene name vapC Uniprot ID E3H592
Locus tag HMPREF0733_RS00860 Protein ID WP_013397524.1
Coordinates 201492..201863 (-) Length 124 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID E3H593
Locus tag HMPREF0733_RS00865 Protein ID WP_013397525.1
Coordinates 201860..202057 (-) Length 66 a.a.

Genomic Context

HMPREF0733_RS00840HMPREF0733_RS00845HMPREF0733_RS00850HMPREF0733_RS00855HMPREF0733_RS00895HMPREF0733_RS00835HMPREF0733_RS00860HMPREF0733_RS00865HMPREF0733_RS00870HMPREF0733_RS00875HMPREF0733_RS00880HMPREF0733_RS00885HMPREF0733_RS00890
Location: 198276..199235 (960 bp)
Type: Others
Protein ID: WP_041321519.1
Location: 199373..199573 (201 bp)
Type: Others
Protein ID: WP_013397521.1
Location: 199903..200718 (816 bp)
Type: Others
Protein ID: WP_013397522.1
Location: 201095..201352 (258 bp)
Type: Others
Protein ID: WP_037231102.1
Location: 206214..206426 (213 bp)
Type: Others
Protein ID: WP_013397532.1
Location: 197344..197976 (633 bp)
Type: Others
Protein ID: WP_041321836.1
Location: 201492..201863 (372 bp)
Type: Toxin
Protein ID: WP_013397524.1
Location: 201860..202057 (198 bp)
Type: Antitoxin
Protein ID: WP_013397525.1
Location: 202124..202819 (696 bp)
Type: Others
Protein ID: Protein_172
Location: 202854..203315 (462 bp)
Type: Others
Protein ID: WP_013397527.1
Location: 203427..203654 (228 bp)
Type: Others
Protein ID: WP_013397528.1
Location: 203881..204621 (741 bp)
Type: Others
Protein ID: WP_080556854.1
Location: 205056..205832 (777 bp)
Type: Others
Protein ID: WP_013397531.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
HMPREF0733_RS00835197344..197976-633WP_041321836.1DJ-1/PfpI family protein-
HMPREF0733_RS00840198276..199235+960WP_041321519.1NADP-dependent oxidoreductase-
HMPREF0733_RS00845199373..199573+201WP_013397521.1hypothetical protein-
HMPREF0733_RS00850199903..200718+816WP_013397522.1class I SAM-dependent methyltransferase-
HMPREF0733_RS00855201095..201352+258WP_037231102.1GlsB/YeaQ/YmgE family stress response membrane protein-
HMPREF0733_RS00860201492..201863-372WP_013397524.1type II toxin-antitoxin system VapC family toxinToxin
HMPREF0733_RS00865201860..202057-198WP_013397525.1type II toxin-antitoxin system VapB family antitoxinAntitoxin
HMPREF0733_RS00870202124..202819-696Protein_172class I SAM-dependent methyltransferase-
HMPREF0733_RS00875202854..203315-462WP_013397527.1DUF2867 domain-containing protein-
HMPREF0733_RS00880203427..203654-228WP_013397528.1YdeI/OmpD-associated family protein-
HMPREF0733_RS00885203881..204621-741WP_080556854.11,4-beta-cellobiosidase-
HMPREF0733_RS00890205056..205832-777WP_013397531.1hypothetical protein-
HMPREF0733_RS00895206214..206426+213WP_013397532.1TOBE domain-containing protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-112)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(1-40)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 14117.25 Da        Isoelectric Point: 5.2122

>T24961 WP_013397524.1 NC_014643:c201863-201492 [Rothia dentocariosa ATCC 17931]
MILVDTNVWIDHLHRTEPELSELLMSDEICCHDLVLTELALGSLKKRNEFLSALSELKQLPTVDDHEVRWFIEKRKLWGR
GLSAVDVHLLASVVVVPGTTLWTRDKRLRDVAQDLGCRFENDG

Download         Length: 372 bp

>T24961 NC_014643:c201863-201492 [Rothia dentocariosa ATCC 17931]
ATGATTTTAGTTGATACCAATGTTTGGATAGATCATCTGCATCGTACAGAGCCCGAACTATCAGAGCTCCTGATGAGTGA
TGAAATTTGCTGTCATGATTTAGTGCTTACAGAACTAGCTCTTGGGTCTCTTAAAAAGCGGAACGAGTTCCTGTCTGCCC
TGAGCGAGCTAAAACAACTTCCCACAGTCGATGATCACGAAGTGCGGTGGTTTATCGAGAAACGTAAGCTGTGGGGACGC
GGTTTATCTGCTGTTGATGTGCACCTTTTAGCCTCGGTTGTGGTAGTTCCAGGAACTACTCTGTGGACTCGTGACAAACG
TTTGCGCGATGTGGCACAAGACCTGGGGTGTCGGTTCGAGAATGATGGATGA

Antitoxin


Download         Length: 66 a.a.        Molecular weight: 7108.25 Da        Isoelectric Point: 10.4580

>AT24961 WP_013397525.1 NC_014643:c202057-201860 [Rothia dentocariosa ATCC 17931]
MRITVTLDEKVVAKVAKLTGIEERSVLVREAMETLLRIENGRLLAALGGSDPQAQAAPRHRNVQS

Download         Length: 198 bp

>AT24961 NC_014643:c202057-201860 [Rothia dentocariosa ATCC 17931]
ATGCGTATAACTGTGACCTTGGATGAAAAAGTTGTTGCTAAGGTGGCGAAACTAACCGGTATTGAAGAACGTTCAGTCTT
GGTGCGTGAGGCTATGGAAACCCTATTACGTATCGAAAATGGGCGTCTGCTCGCTGCATTAGGAGGTTCCGACCCTCAAG
CCCAGGCGGCTCCGCGGCATCGAAATGTGCAGTCATGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBE3H592

Antitoxin

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Source
ID
Structure
AlphaFold DBE3H593

References