Detailed information of TA system TA024961

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VapB
• Location: 201492..202057
• Replicon: chromosome
• Accession: NC_014643
• Organism: Rothia dentocariosa ATCC 17931

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: E3H592
• Locus tag: HMPREF0733_RS00860
• Protein ID: WP_013397524.1
• Coordinates: 201492..201863 (-)
• Length: 124 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: E3H593
• Locus tag: HMPREF0733_RS00865
• Protein ID: WP_013397525.1
• Coordinates: 201860..202057 (-)
• Length: 66 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HMPREF0733_RS00835	197344..197976	-	633	WP_041321836.1	DJ-1/PfpI family protein	-
HMPREF0733_RS00840	198276..199235	+	960	WP_041321519.1	NADP-dependent oxidoreductase	-
HMPREF0733_RS00845	199373..199573	+	201	WP_013397521.1	hypothetical protein	-
HMPREF0733_RS00850	199903..200718	+	816	WP_013397522.1	class I SAM-dependent methyltransferase	-
HMPREF0733_RS00855	201095..201352	+	258	WP_037231102.1	GlsB/YeaQ/YmgE family stress response membrane protein	-
HMPREF0733_RS00860	201492..201863	-	372	WP_013397524.1	type II toxin-antitoxin system VapC family toxin	Toxin
HMPREF0733_RS00865	201860..202057	-	198	WP_013397525.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
HMPREF0733_RS00870	202124..202819	-	696	Protein_172	class I SAM-dependent methyltransferase	-
HMPREF0733_RS00875	202854..203315	-	462	WP_013397527.1	DUF2867 domain-containing protein	-
HMPREF0733_RS00880	203427..203654	-	228	WP_013397528.1	YdeI/OmpD-associated family protein	-
HMPREF0733_RS00885	203881..204621	-	741	WP_080556854.1	1,4-beta-cellobiosidase	-
HMPREF0733_RS00890	205056..205832	-	777	WP_013397531.1	hypothetical protein	-
HMPREF0733_RS00895	206214..206426	+	213	WP_013397532.1	TOBE domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-112)

Antitoxin

• Bacterial antitoxin of type II TA system, VapB (1-40)

Sequences

Toxin

Protein

• Length: 124 a.a.
• Molecular weight: 14117.25 Da
• Isoelectric Point: 5.2122

>T24961 WP_013397524.1 NC_014643:c201863-201492 [Rothia dentocariosa ATCC 17931]
MILVDTNVWIDHLHRTEPELSELLMSDEICCHDLVLTELALGSLKKRNEFLSALSELKQLPTVDDHEVRWFIEKRKLWGR
GLSAVDVHLLASVVVVPGTTLWTRDKRLRDVAQDLGCRFENDG

Nucleotide

• Length: 372 bp

>T24961 NC_014643:c201863-201492 [Rothia dentocariosa ATCC 17931]
ATGATTTTAGTTGATACCAATGTTTGGATAGATCATCTGCATCGTACAGAGCCCGAACTATCAGAGCTCCTGATGAGTGA
TGAAATTTGCTGTCATGATTTAGTGCTTACAGAACTAGCTCTTGGGTCTCTTAAAAAGCGGAACGAGTTCCTGTCTGCCC
TGAGCGAGCTAAAACAACTTCCCACAGTCGATGATCACGAAGTGCGGTGGTTTATCGAGAAACGTAAGCTGTGGGGACGC
GGTTTATCTGCTGTTGATGTGCACCTTTTAGCCTCGGTTGTGGTAGTTCCAGGAACTACTCTGTGGACTCGTGACAAACG
TTTGCGCGATGTGGCACAAGACCTGGGGTGTCGGTTCGAGAATGATGGATGA

Antitoxin

Protein

• Length: 66 a.a.
• Molecular weight: 7108.25 Da
• Isoelectric Point: 10.4580

>AT24961 WP_013397525.1 NC_014643:c202057-201860 [Rothia dentocariosa ATCC 17931]
MRITVTLDEKVVAKVAKLTGIEERSVLVREAMETLLRIENGRLLAALGGSDPQAQAAPRHRNVQS

Nucleotide

• Length: 198 bp

>AT24961 NC_014643:c202057-201860 [Rothia dentocariosa ATCC 17931]
ATGCGTATAACTGTGACCTTGGATGAAAAAGTTGTTGCTAAGGTGGCGAAACTAACCGGTATTGAAGAACGTTCAGTCTT
GGTGCGTGAGGCTATGGAAACCCTATTACGTATCGAAAATGGGCGTCTGCTCGCTGCATTAGGAGGTTCCGACCCTCAAG
CCCAGGCGGCTCCGCGGCATCGAAATGTGCAGTCATGA

Structures

Toxin

• AlphaFold DB: E3H592

Antitoxin

• AlphaFold DB: E3H593