Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataT-KacA/DUF1778(antitoxin)
Location 31649..32447 Replicon plasmid plas1
Accession NZ_CP099875
Organism Escherichia albertii strain 251_2_EW_B

Toxin (Protein)


Gene name ataT Uniprot ID E2QDF3
Locus tag NIZ23_RS23095 Protein ID WP_000072677.1
Coordinates 31926..32447 (+) Length 174 a.a.

Antitoxin (Protein)


Gene name KacA Uniprot ID A0A0V9R6Q7
Locus tag NIZ23_RS23090 Protein ID WP_001351987.1
Coordinates 31649..31918 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NIZ23_RS23065 (NIZ23_23045) 27076..28416 - 1341 WP_000137333.1 DnaB-like helicase C-terminal domain-containing protein -
NIZ23_RS23070 (NIZ23_23050) 28460..29200 - 741 WP_187192596.1 hypothetical protein -
NIZ23_RS23075 (NIZ23_23055) 29483..30250 + 768 WP_000342417.1 hypothetical protein -
NIZ23_RS23080 (NIZ23_23060) 30303..30656 - 354 WP_160378290.1 hypothetical protein -
NIZ23_RS23085 (NIZ23_23065) 30662..31330 - 669 WP_000161228.1 division plane positioning ATPase MipZ -
NIZ23_RS23090 (NIZ23_23070) 31649..31918 + 270 WP_001351987.1 DUF1778 domain-containing protein Antitoxin
NIZ23_RS23095 (NIZ23_23075) 31926..32447 + 522 WP_000072677.1 GNAT family N-acetyltransferase Toxin
NIZ23_RS23100 (NIZ23_23080) 32616..32867 - 252 WP_000901559.1 hypothetical protein -
NIZ23_RS23105 (NIZ23_23085) 32869..33561 - 693 WP_012640731.1 hypothetical protein -
NIZ23_RS23110 (NIZ23_23090) 33575..33898 - 324 WP_000064175.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..109380 109380


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(72-150)

Antitoxin

Vibrio phage ICP1, Orf50

(8-86)


Sequences

Toxin        


Download         Length: 174 a.a.        Molecular weight: 19392.17 Da        Isoelectric Point: 8.6369

>T249609 WP_000072677.1 NZ_CP099875:31926-32447 [Escherichia albertii]
VSNTTIEIFSGEKDYDLNGFDCGEESLNAFLANHLKRQHEGKILRAYVLCTQEERPKVLGYYTLSGSCFEKESLPSRSKQ
KKVPYRNVPSVTLGRLALDKSLQGQGFGSMLVTHAMRVVYNASLAVGIHGLFVEALNDKAKAFYKSLGFIQLVGNNERSL
FYPTKSIEKLFEE

Download         Length: 522 bp

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10082.54 Da        Isoelectric Point: 7.0155

>AT249609 WP_001351987.1 NZ_CP099875:31649-31918 [Escherichia albertii]
MSALKKQRIDLRLTDDDKSIIEEAAAMSNQSITQFMVSSASERAVKVIEQHRRLVLNEESWNLVMDAISNPPAPNDKLKR
AADRLKSME

Download         Length: 270 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0V9R6P3

Antitoxin

Source ID Structure
AlphaFold DB A0A0V9R6Q7

References