Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3481783..3482401 Replicon chromosome
Accession NZ_CP099874
Organism Escherichia albertii strain 251_2_EW_B

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag NIZ23_RS17070 Protein ID WP_001280991.1
Coordinates 3482183..3482401 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID -
Locus tag NIZ23_RS17065 Protein ID WP_256878553.1
Coordinates 3481783..3482157 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NIZ23_RS17055 (3476863) 3476863..3478056 + 1194 WP_010334435.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
NIZ23_RS17060 (3478079) 3478079..3481228 + 3150 WP_001132500.1 efflux RND transporter permease AcrB -
NIZ23_RS17065 (3481783) 3481783..3482157 + 375 WP_256878553.1 Hha toxicity modulator TomB Antitoxin
NIZ23_RS17070 (3482183) 3482183..3482401 + 219 WP_001280991.1 HHA domain-containing protein Toxin
NIZ23_RS17075 (3482578) 3482578..3483135 + 558 WP_025237467.1 maltose O-acetyltransferase -
NIZ23_RS17080 (3483242) 3483242..3483712 + 471 WP_000136188.1 YlaC family protein -
NIZ23_RS17085 (3483876) 3483876..3485425 + 1550 Protein_3334 EAL domain-containing protein -
NIZ23_RS17090 (3485463) 3485463..3485816 - 354 WP_000878151.1 DUF1428 family protein -
NIZ23_RS17100 (3486197) 3486197..3486508 + 312 WP_000409915.1 MGMT family protein -
NIZ23_RS17105 (3486538) 3486538..3487110 - 573 WP_256875765.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T249601 WP_001280991.1 NZ_CP099874:3482183-3482401 [Escherichia albertii]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14455.34 Da        Isoelectric Point: 5.1542

>AT249601 WP_256878553.1 NZ_CP099874:3481783-3482157 [Escherichia albertii]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQALQKWRKSGNRLFRCFVNATKANPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure

References