Detailed information of TA system TA024958

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 5038198..5038834
• Replicon: chromosome
• Accession: NC_014640
• Organism: Achromobacter xylosoxidans A8

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: AXYL_RS34450
• Protein ID: WP_013395339.1
• Coordinates: 5038198..5038380 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: AXYL_RS23365
• Protein ID: WP_041654201.1
• Coordinates: 5038442..5038834 (+)
• Length: 131 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AXYL_RS23350	5034285..5034758	+	474	WP_013395336.1	(2Fe-2S)-binding protein	-
AXYL_RS23355	5034755..5037046	+	2292	WP_013395337.1	xanthine dehydrogenase family protein molybdopterin-binding subunit	-
AXYL_RS23360	5037049..5038119	+	1071	WP_013395338.1	XdhC family protein	-
AXYL_RS34450	5038198..5038380	+	183	WP_013395339.1	type II toxin-antitoxin system HicA family toxin	Toxin
AXYL_RS23365	5038442..5038834	+	393	WP_041654201.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
AXYL_RS23375	5039121..5039705	-	585	WP_013395341.1	XRE family transcriptional regulator	-
AXYL_RS23380	5039718..5041010	-	1293	WP_041655948.1	FAD-binding oxidoreductase	-
AXYL_RS23385	5041022..5041711	-	690	WP_013395343.1	amino acid ABC transporter permease	-
AXYL_RS23390	5041714..5042406	-	693	WP_013395344.1	amino acid ABC transporter permease	-
AXYL_RS23395	5042411..5043202	-	792	WP_013395345.1	ABC transporter substrate-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-127)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6641.84 Da
• Isoelectric Point: 11.0007

>T24958 WP_013395339.1 NC_014640:5038198-5038380 [Achromobacter xylosoxidans A8]
MDSKELIKQLERSGWKLRGVKGSHHVFIHPDRPGHISVPHPKKDLGIGLLNSILKAAGLK

Nucleotide

• Length: 183 bp

>T24958 NC_014640:5038198-5038380 [Achromobacter xylosoxidans A8]
ATGGACAGCAAGGAACTGATCAAACAGCTAGAGCGGTCCGGGTGGAAACTGCGAGGAGTTAAGGGCTCCCACCATGTTTT
CATCCACCCAGACCGCCCCGGACATATCAGCGTCCCTCACCCTAAAAAGGACCTCGGCATCGGACTACTAAACAGCATCC
TCAAAGCAGCTGGTTTGAAGTGA

Antitoxin

Protein

• Length: 131 a.a.
• Molecular weight: 14082.79 Da
• Isoelectric Point: 4.2244

>AT24958 WP_041654201.1 NC_014640:5038442-5038834 [Achromobacter xylosoxidans A8]
VKYPIAIEPGSDTHAWGVVVPDLPGCFSAADEGIDQAIENAKEAIELWIETAIDSGDPIPPATSIANHQANPEFANWIWA
IADVDPAVLDETVERVNITIPRRILKRLDDRARAAGESRSSYIAHLAMTA

Nucleotide

• Length: 393 bp

>AT24958 NC_014640:5038442-5038834 [Achromobacter xylosoxidans A8]
GTGAAATATCCCATTGCCATTGAACCCGGCAGCGACACTCACGCGTGGGGGGTCGTGGTCCCTGATCTGCCCGGCTGCTT
CTCGGCAGCGGACGAAGGGATTGACCAAGCCATCGAAAACGCCAAGGAAGCCATTGAATTGTGGATTGAAACGGCCATCG
ACTCCGGCGATCCCATTCCTCCGGCAACCAGTATTGCCAATCATCAGGCCAATCCGGAATTTGCAAACTGGATTTGGGCG
ATTGCTGATGTGGATCCTGCGGTCCTCGATGAAACTGTTGAGCGCGTGAACATCACCATTCCGCGCCGCATCCTCAAGCG
CTTGGATGACCGCGCTCGCGCCGCAGGTGAAAGCCGCAGCAGCTATATCGCGCATCTCGCCATGACAGCCTGA