Detailed information of TA system TA024957

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/upstrm_HI1419-dnstrm_HI1420
• Location: 3616286..3616927
• Replicon: chromosome
• Accession: NC_014640
• Organism: Achromobacter xylosoxidans A8

Toxin (Protein)

• Gene name: relE
• Uniprot ID: E3HHX6
• Locus tag: AXYL_RS16655
• Protein ID: WP_013393991.1
• Coordinates: 3616286..3616603 (+)
• Length: 106 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: AXYL_RS16660
• Protein ID: WP_013393992.1
• Coordinates: 3616607..3616927 (+)
• Length: 107 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AXYL_RS16635	3611516..3612676	+	1161	WP_013393987.1	acyl-CoA/acyl-ACP dehydrogenase	-
AXYL_RS16640	3612693..3614069	+	1377	WP_013393988.1	MmgE/PrpD family protein	-
AXYL_RS16645	3614136..3614852	-	717	WP_193353251.1	ribonuclease PH	-
AXYL_RS16650	3615057..3615989	+	933	WP_013393990.1	YicC family protein	-
AXYL_RS16655	3616286..3616603	+	318	WP_013393991.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
AXYL_RS16660	3616607..3616927	+	321	WP_013393992.1	putative addiction module antidote protein	Antitoxin
AXYL_RS16665	3617002..3618489	-	1488	WP_148260709.1	amino acid permease	-
AXYL_RS16670	3618697..3620193	-	1497	WP_041655671.1	AMP nucleosidase	-
AXYL_RS16675	3620509..3621108	+	600	WP_013393995.1	C40 family peptidase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Addiction module killer protein, predicted (10-102)

Antitoxin

• Uncharacterized protein HI1420 (13-102)

Sequences

Toxin

Protein

• Length: 106 a.a.
• Molecular weight: 12205.21 Da
• Isoelectric Point: 10.4603

>T24957 WP_013393991.1 NC_014640:3616286-3616603 [Achromobacter xylosoxidans A8]
MSWFTINPIEVVQSREFKVWHDNLRDRIARARITARINLAEHGNLGDWKPLRDGISEMRIDVGPGYRLYFTRRGNKIIVL
LCGGDKAKQDIDIKRAIDLAKMLKE

Nucleotide

• Length: 318 bp

>T24957 NC_014640:3616286-3616603 [Achromobacter xylosoxidans A8]
ATGTCATGGTTCACAATAAATCCAATTGAAGTCGTCCAAAGTCGCGAGTTCAAAGTTTGGCATGACAATCTGCGCGACAG
GATTGCCCGCGCACGCATTACAGCCAGAATCAACCTTGCCGAGCACGGCAATCTGGGCGACTGGAAGCCCTTGCGCGATG
GCATTTCGGAAATGCGTATCGACGTCGGTCCCGGCTATCGCCTGTACTTCACCCGCCGCGGCAACAAAATAATTGTGTTG
CTGTGCGGTGGCGACAAGGCAAAGCAGGACATTGACATCAAGCGCGCCATCGATCTCGCCAAAATGCTGAAGGAGTGA

Antitoxin

Protein

• Length: 107 a.a.
• Molecular weight: 11499.08 Da
• Isoelectric Point: 6.2226

>AT24957 WP_013393992.1 NC_014640:3616607-3616927 [Achromobacter xylosoxidans A8]
MSEHLNADIPAGFSRWDAADTLKTDEDAVLYFEACLAEDPGDGSLIRAALGDIARARGMSQLARETGLSREGLYQALSAK
GNPEFSTIMKVIRALRLKLHAKIAHT

Nucleotide

• Length: 321 bp

>AT24957 NC_014640:3616607-3616927 [Achromobacter xylosoxidans A8]
ATGAGCGAACATCTCAACGCCGACATCCCCGCAGGATTCAGCCGATGGGATGCCGCTGACACCCTCAAGACCGATGAAGA
TGCCGTACTGTATTTCGAAGCTTGCCTGGCGGAAGACCCAGGCGATGGCAGCCTGATCCGAGCGGCCTTGGGCGACATCG
CCCGCGCGCGCGGCATGAGCCAGCTTGCCCGCGAGACGGGTCTATCCCGCGAAGGGCTGTATCAGGCGCTGTCCGCCAAA
GGCAACCCGGAGTTCAGCACCATCATGAAAGTGATCCGTGCCTTGAGACTCAAACTACACGCGAAGATTGCACACACTTG
A

Structures

Toxin

• AlphaFold DB: E3HHX6