Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 885421..886072 Replicon chromosome
Accession NZ_CP099871
Organism Escherichia albertii strain 253_2_EW_B

Toxin (Protein)


Gene name cptA Uniprot ID B1EG01
Locus tag NIZ24_RS04285 Protein ID WP_000244763.1
Coordinates 885668..886072 (+) Length 135 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag NIZ24_RS04280 Protein ID WP_000354046.1
Coordinates 885421..885687 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NIZ24_RS04255 (881132) 881132..882565 - 1434 WP_059235410.1 6-phospho-beta-glucosidase BglA -
NIZ24_RS04260 (882610) 882610..882921 + 312 WP_001182957.1 N(4)-acetylcytidine aminohydrolase -
NIZ24_RS04265 (883089) 883089..883748 + 660 WP_000250281.1 hemolysin III family protein -
NIZ24_RS04270 (884189) 884189..885169 - 981 WP_059235393.1 tRNA-modifying protein YgfZ -
NIZ24_RS04275 (885201) 885201..885431 + 231 WP_000181267.1 hypothetical protein -
NIZ24_RS04280 (885421) 885421..885687 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
NIZ24_RS04285 (885668) 885668..886072 + 405 WP_000244763.1 protein YgfX Toxin
NIZ24_RS04290 (886111) 886111..886632 - 522 WP_059235395.1 flavodoxin FldB -
NIZ24_RS04295 (886744) 886744..887640 + 897 WP_059228147.1 site-specific tyrosine recombinase XerD -
NIZ24_RS04300 (887665) 887665..888375 + 711 WP_256878190.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
NIZ24_RS04305 (888381) 888381..890114 + 1734 WP_000813238.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 15888.81 Da        Isoelectric Point: 11.1732

>T249569 WP_000244763.1 NZ_CP099871:885668-886072 [Escherichia albertii]
VVLWQSDLRVSWRAQWLSLLIHGLVAAAILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVRAPWMIKTGMMLRLLSDSGKRQHLWLAADSMDEAEWRDLRRILLQQEIQ

Download         Length: 405 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT249569 WP_000354046.1 NZ_CP099871:885421-885687 [Escherichia albertii]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2S6P9B3

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References